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Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada

Skowronski, Danuta M ; De Serres, Gaston ; Crowcroft, Natasha S ; Janjua, Naveed Z ; Boulianne, Nicole ; Hottes, Travis S ; Rosella, Laura C ; Dickinson, James A ; Gilca, Rodica ; Sethi, Pam ; Ouhoummane, Najwa ; Willison, Donald J ; Rouleau, Isabelle ; Petric, Martin ; Fonseca, Kevin ; Drews, Steven J ; Rebbapragada, Anuradha ; Charest, Hugues ; Hamelin, Marie-Eve ; Boivin, Guy ; Gardy, Jennifer L ; Li, Yan ; Kwindt, Trijntje L ; Patrick, David M ; Brunham, Robert C Simonsen, Lone

PLoS medicine, 2010-04, Vol.7 (4), p.e1000258 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada
Autor: Skowronski, Danuta M ; De Serres, Gaston ; Crowcroft, Natasha S ; Janjua, Naveed Z ; Boulianne, Nicole ; Hottes, Travis S ; Rosella, Laura C ; Dickinson, James A ; Gilca, Rodica ; Sethi, Pam ; Ouhoummane, Najwa ; Willison, Donald J ; Rouleau, Isabelle ; Petric, Martin ; Fonseca, Kevin ; Drews, Steven J ; Rebbapragada, Anuradha ; Charest, Hugues ; Hamelin, Marie-Eve ; Boivin, Guy ; Gardy, Jennifer L ; Li, Yan ; Kwindt, Trijntje L ; Patrick, David M ; Brunham, Robert C
Simonsen, Lone
Assuntos: Canada - epidemiology ; Demographic aspects ; Disease Outbreaks ; Forecasts and trends ; Humans ; Illnesses ; Infectious Diseases ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Respiratory Infections ; Infectious Diseases/Viral Infections ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Influenza Vaccines - adverse effects ; Influenza, Human - epidemiology ; Influenza, Human - virology ; Medical research ; Methods ; Observation ; Observational studies ; Pandemics ; Public health ; Public Health and Epidemiology ; Public Health and Epidemiology/Immunization ; Public Health and Epidemiology/Infectious Diseases ; Public Health and Epidemiology/Preventive Medicine ; Respiratory Medicine/Respiratory Infections ; Studies ; Swine flu ; Swine influenza ; Vaccination ; Vaccines
É parte de: PLoS medicine, 2010-04, Vol.7 (4), p.e1000258
Notas: ICMJE criteria for authorship read and met: DMS GDS NSC NZJ NB TSH LCR JAD RG PS NO DJW IR MP KF SJD AR HC MH GB JLG YL TLK DMP RCB. Agree with the manuscript's results and conclusions: DMS GDS NSC NZJ NB TSH LCR JAD RG PS NO DJW IR MP KF SJD AR HC MH GB JLG YL TLK DMP RCB. Designed the experiments/the study: DMS GDS NSC NZJ NB TSH LCR RG PS IR MP SJD AR GB DMP. Analyzed the data: DMS GDS NSC NZJ NB TSH LCR RG NO IR MH YL DMP RCB. Collected data/did experiments for the study: DMS GDS NSC NZJ NB JAD RG PS MP KF SJD AR HC MH GB YL TLK. Enrolled patients: GDS NSC JAD RG PS SJD GB. Wrote the first draft of the paper: DMS. Contributed to the writing of the paper: DMS GDS NSC NZJ NB TSH LCR JAD RG PS DJW IR MP KF SJD AR GB TLK DMP RCB. Overall Principal Investigator for the sentinel study and Principal Investigator for the British Columbia component: DMS. First author responsible for drafting and revising the overall manuscript describing the four studies, with collective co-author input: DMS. Principal Investigator for the Quebec component of the sentinel study and Principal Investigator for the Quebec case-control and cohort studies: GDS. Principal Investigator for the Ontario component of the sentinel study and Principal Investigator of the Ontario case-control study: NSC. Principal Investigator for the Alberta component of the sentinel study: JAD. Contributed to the design of the Ontario case-control study data collection strategy: DJW. As clinical virologist and co-investigator on the sentinel study, supervised the diagnostic testing for influenza for patient specimens from British Columbia (MP), Alberta (KF), Ontario (SJD) or Quebec (HC). Member of the original granting team responsible for setting up a network in the province of Ontario that collected data and supported clinical lab testing: SJD. Designed, executed, and analyzed the bioinformatics portion of the study: JLG. Developed molecular assay for detection of pandemic H1N1 virus: YL. Designed the data entry tool and coordinated implementation with provinces participating in the sentinel study: TLK
Members of the Canadian SAVOIR Team are listed in the Acknowledgments.
Descrição: In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association. (1) test-negative case-control design based on Canada's sentinel vaccine effectiveness monitoring system in British Columbia, Alberta, Ontario, and Quebec; (2) conventional case-control design using population controls in Quebec; (3) test-negative case-control design in Ontario; and (4) prospective household transmission (cohort) study in Quebec. Logistic regression was used to estimate odds ratios for TIV effect on community- or hospital-based laboratory-confirmed seasonal or pH1N1 influenza cases compared to controls with restriction, stratification, and adjustment for covariates including combinations of age, sex, comorbidity, timeliness of medical visit, prior physician visits, and/or health care worker (HCW) status. For the prospective study risk ratios were computed. Based on the sentinel study of 672 cases and 857 controls, 2008-09 TIV was associated with statistically significant protection against seasonal influenza (odds ratio 0.44, 95% CI 0.33-0.59). In contrast, estimates from the sentinel and three other observational studies, involving a total of 1,226 laboratory-confirmed pH1N1 cases and 1,505 controls, indicated that prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009, with estimated risk or odds ratios ranging from 1.4 to 2.5. Risk of pH1N1 hospitalization was not further increased among vaccinated people when comparing hospitalized to community cases. Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada. The occurrence of bias (selection, information) or confounding cannot be ruled out. Further experimental and epidemiological assessment is warranted. Possible biological mechanisms and immunoepidemiologic implications are considered.
Editor: United States: Public Library of Science
Idioma: Inglês

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Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada

United States: Public Library of Science

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