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Nano-scale drug delivery systems for antiarrhythmic agents

Nadimi, Ali Esmaeili ; Ebrahimipour, S. Yousef ; Afshar, Elham Ghasemipour ; Falahati-pour, Soudeh Khanamani ; Ahmadi, Zahra ; Mohammadinejad, Reza ; Mohamadi, Maryam

European journal of medicinal chemistry, 2018-09, Vol.157, p.1153-1163 [Periódico revisado por pares]

France: Elsevier Masson SAS

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Título:
Nano-scale drug delivery systems for antiarrhythmic agents
Autor: Nadimi, Ali Esmaeili ; Ebrahimipour, S. Yousef ; Afshar, Elham Ghasemipour ; Falahati-pour, Soudeh Khanamani ; Ahmadi, Zahra ; Mohammadinejad, Reza ; Mohamadi, Maryam
Assuntos: Animals ; Anti-Arrhythmia Agents - administration & dosage ; Anti-Arrhythmia Agents - chemistry ; Anti-Arrhythmia Agents - pharmacology ; Anti-Arrhythmia Agents - therapeutic use ; Antiarrhythmic agents ; Arrhythmias ; Arrhythmias, Cardiac - drug therapy ; Cardiovascular diseases ; Dose-Response Relationship, Drug ; Drug Delivery Systems - methods ; Humans ; Molecular Structure ; Nano drug delivery systems ; Nano-encapsulation ; Nanomedicine - methods ; Structure-Activity Relationship
É parte de: European journal of medicinal chemistry, 2018-09, Vol.157, p.1153-1163
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Arrhythmia means the heart is beating too fast, too slow, or with an irregular pattern. Due to the side effects and low bioavailability of many antiarrhythmic drugs, nano-encapsulation has been widely used for their targeted delivery. Lipid nanocapsules, nano liposomes, nano niosomes, solid lipid nanoparticles and polymeric nanoparticles are common nano-carriers used for this purpose. The aim of this article is to summarize some of nano systems used for the specific delivery of antiarrhythmic agents to target tissues. At first, nanotechnology and its applications in drug delivery are described in brief. Then, some information on arrhythmias and antiarrhythmic drugs are provided. Finally, the nano drug delivery systems are explained and examples of their applications in encapsulation of antiarrhythmic drugs are presented. [Display omitted] •Nanomedicine has been found many applications in efficient targeted therapy.•Different nano-carriers have been used for the delivery of antiarrhythmic drugs.•Liposomes, niosomes, and polymeric nanoparticles have been frequently used.•These systems overcome the side effects and low bioavailability of the drugs.
Editor: France: Elsevier Masson SAS
Idioma: Inglês

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Nano-scale drug delivery systems for antiarrhythmic agents

Nadimi, Ali Esmaeili ; Ebrahimipour, S. Yousef ; Afshar, Elham Ghasemipour ; Falahati-pour, Soudeh Khanamani ; Ahmadi, Zahra ; Mohammadinejad, Reza ; Mohamadi, Maryam

France: Elsevier Masson SAS

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