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Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi

Almeida, Gregório Guilherme ; Costa, Pedro Augusto Carvalho ; Araujo, Maísa da Silva ; Gomes, Gabriela Ribeiro ; Carvalho, Alex Fiorini ; Figueiredo, Maria Marta ; Pereira, Dhelio Batista ; Tada, Mauro Shugiro ; Medeiros, Jansen Fernandes ; Soares, Irene da Silva ; Carvalho, Luzia Helena ; Kano, Flora Satiko ; Castro, Marcia Caldas de ; Vinetz, Joseph Michael ; Golenbock, Douglas Taylor ; Antonelli, Lis Ribeiro do Valle ; Gazzinelli, Ricardo Tostes Sinnis, Photini

PLoS neglected tropical diseases, 2021-10, Vol.15 (10), p.e0009077-e0009077 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi
Autor: Almeida, Gregório Guilherme ; Costa, Pedro Augusto Carvalho ; Araujo, Maísa da Silva ; Gomes, Gabriela Ribeiro ; Carvalho, Alex Fiorini ; Figueiredo, Maria Marta ; Pereira, Dhelio Batista ; Tada, Mauro Shugiro ; Medeiros, Jansen Fernandes ; Soares, Irene da Silva ; Carvalho, Luzia Helena ; Kano, Flora Satiko ; Castro, Marcia Caldas de ; Vinetz, Joseph Michael ; Golenbock, Douglas Taylor ; Antonelli, Lis Ribeiro do Valle ; Gazzinelli, Ricardo Tostes
Sinnis, Photini
Assuntos: Animals ; Anopheles ; Anopheles - parasitology ; Anopheles - physiology ; Antibodies ; Aquatic insects ; Asymptomatic ; Asymptomatic infection ; Asymptomatic Infections - epidemiology ; Biology and Life Sciences ; Blood ; Blood - parasitology ; Brazil - epidemiology ; Carrier state (Communicable diseases) ; Cohort Studies ; Cohorts ; Comparative analysis ; Cross-Sectional Studies ; Disease transmission ; Endemism ; Female ; Health aspects ; Human diseases ; Humans ; Identification and classification ; Infection ; Infections ; Infectivity ; Malaria ; Malaria, Vivax - epidemiology ; Malaria, Vivax - parasitology ; Malaria, Vivax - transmission ; Male ; Medicine and Health Sciences ; Microscopy ; Middle Aged ; Mosquitoes ; Parasitemia ; Parasites ; Plasmodium falciparum ; Plasmodium vivax ; Plasmodium vivax - genetics ; Plasmodium vivax - physiology ; Research and Analysis Methods ; Risk factors ; Seasons ; Statistics ; Suburban areas ; Transmission ; Tropical diseases ; Urban population ; Vaccines ; Vector-borne diseases
É parte de: PLoS neglected tropical diseases, 2021-10, Vol.15 (10), p.e0009077-e0009077
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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The authors have declared that no competing interests exist.
Descrição: Individuals with asymptomatic infection due to Plasmodium vivax are posited to be important reservoirs of malaria transmission in endemic regions. Here we studied a cohort of P. vivax malaria patients in a suburban area in the Brazilian Amazon. Overall 1,120 individuals were screened for P. vivax infection and 108 (9.6%) had parasitemia detected by qPCR but not by microscopy. Asymptomatic individuals had higher levels of antibodies against P. vivax and similar hematological and biochemical parameters compared to uninfected controls. Blood from asymptomatic individuals with very low parasitemia transmitted P. vivax to the main local vector, Nyssorhynchus darlingi. Lower mosquito infectivity rates were observed when blood from asymptomatic individuals was used in the membrane feeding assay. While blood from symptomatic patients infected 43.4% (199/458) of the mosquitoes, blood from asymptomatic infected 2.5% (43/1,719). However, several asymptomatic individuals maintained parasitemia for several weeks indicating their potential role as an infectious reservoir. These results suggest that asymptomatic individuals are an important source of malaria parasites and Science and Technology for Vaccines granted by Conselho Nacional de may contribute to the transmission of P. vivax in low-endemicity areas of malaria.
Editor: United States: Public Library of Science
Idioma: Inglês

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Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi

United States: Public Library of Science

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