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Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations

Whitehead, Daisy L. ; Davies, Ann D.M. ; Playfer, Jeremy R. ; Turnbull, Christopher J.

Movement disorders, 2008-06, Vol.23 (8), p.1137-1145 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations
Autor: Whitehead, Daisy L. ; Davies, Ann D.M. ; Playfer, Jeremy R. ; Turnbull, Christopher J.
Assuntos: actigraphy ; Aged ; Aged, 80 and over ; Antiparkinson Agents - therapeutic use ; Biological and medical sciences ; circadian ; Circadian Rhythm ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine Agonists - therapeutic use ; Female ; hallucinations ; Hallucinations - diagnosis ; Hallucinations - drug therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Monitoring, Ambulatory ; Motor Activity ; Neurology ; Parkinson Disease - diagnosis ; Parkinson Disease - drug therapy ; Parkinson's disease ; Reference Values ; Rest ; rest-activity rhythm ; Sleep Disorders, Circadian Rhythm - diagnosis
É parte de: Movement disorders, 2008-06, Vol.23 (8), p.1137-1145
Notas: ArticleID:MDS22057
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Descrição: The sleep‐wake cycle in Parkinson's Disease (PD) is profoundly disrupted, but less is known about circadian rhythm in PD and its relationship to other important clinical features. This study compared rest‐activity rhythms in healthy older adults and PD patients with and without hallucinations. Twenty‐nine older adults and 50 PD patients (27 with hallucinations, 23 without) were assessed using wrist‐worn actigraphy for 5 days. Disease‐related and cognitive data were also collected. PD patients demonstrated reduced amplitude of activity (F = 12.719, P < 0.01) and increased intradaily variability (F = 22.005, P < 0.001), compared to healthy older adults, independently of age, and cognitive status. Hallucinators showed lower interdaily stability (F = 7.493, P < 0.01) significantly greater activity during “night‐time” (F = 6.080, P < 0.05) and significantly reduced relative amplitude of activity (F = 5.804, P < 0.05) compared to nonhallucinators, independently of clinical factors including motor fluctuations. PD patients with hallucinations display altered rest‐activity rhythm characterized by an unpredictable circadian pattern across days, likely arising from damage to brainstem and hypothalamic sleep centers. Treatment of sleep and rest‐activity rhythm disturbance is an important target in Parkinson's Disease. © 2008 Movement Disorder Society.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations

Whitehead, Daisy L. ; Davies, Ann D.M. ; Playfer, Jeremy R. ; Turnbull, Christopher J.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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