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Reversal of social deficits by subchronic oxytocin in two autism mouse models

Teng, Brian L. ; Nikolova, Viktoriya D. ; Riddick, Natallia V. ; Agster, Kara L. ; Crowley, James J. ; Baker, Lorinda K. ; Koller, Beverly H. ; Pedersen, Cort A. ; Jarstfer, Michael B. ; Moy, Sheryl S.

Neuropharmacology, 2016-06, Vol.105, p.61-71 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Reversal of social deficits by subchronic oxytocin in two autism mouse models
Autor: Teng, Brian L. ; Nikolova, Viktoriya D. ; Riddick, Natallia V. ; Agster, Kara L. ; Crowley, James J. ; Baker, Lorinda K. ; Koller, Beverly H. ; Pedersen, Cort A. ; Jarstfer, Michael B. ; Moy, Sheryl S.
Assuntos: Animals ; Autism Spectrum Disorder - physiopathology ; Autism Spectrum Disorder - prevention & control ; Autism Spectrum Disorder - psychology ; Autism spectrum disorders ; Behavior, Animal - drug effects ; Choice Behavior - drug effects ; Clozapine ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; Hyperkinesis - chemically induced ; Male ; Medicin och hälsovetenskap ; Mice ; Nerve Tissue Proteins - genetics ; Oxytocin ; Oxytocin - administration & dosage ; Prepulse Inhibition - drug effects ; Receptors, N-Methyl-D-Aspartate - genetics ; Risperidone ; Schizophrenia ; Sociability ; Social Behavior
É parte de: Neuropharmacology, 2016-06, Vol.105, p.61-71
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: Kara Agster Saddoris, Ph.D., Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309-0345, USA.
Present address: Brian L. Teng, Ph.D., Biogen Idec, Corporate Strategy Division, Cambridge, MA 02142, USA.
Descrição: Social deficits are a hallmark feature of autism spectrum disorder (ASD) and related developmental syndromes. Although there is no standard treatment for social dysfunction, clinical studies have identified oxytocin as a potential therapeutic with prosocial efficacy. We have previously reported that peripheral oxytocin treatment can increase sociability and ameliorate repetitive stereotypy in adolescent mice from the C58/J model of ASD-like behavior. In the present study, we determined that prosocial oxytocin effects were not limited to the adolescent period, since C58/J mice, tested in adulthood, demonstrated significant social preference up to 2 weeks following subchronic oxytocin treatment. Oxytocin was also evaluated in adult mice with underexpression of the N-methyl-d-aspartate receptor NR1 subunit (encoded by Grin1), a genetic model of autism- and schizophrenia-like behavior. Subchronic oxytocin had striking prosocial efficacy in male Grin1 knockdown mice; in contrast, chronic regimens with clozapine (66 mg/kg/day) or risperidone (2 mg/kg/day) failed to reverse deficits in sociability. Neither the subchronic oxytocin regimen, nor chronic treatment with clozapine or risperidone, reversed impaired prepulse inhibition in the Grin1 knockdown mice. Overall, these studies demonstrate oxytocin can enhance sociability in mouse models with divergent genotypes and behavioral profiles, adding to the evidence that this neurohormone could have therapeutic prosocial efficacy across a spectrum of developmental disorders. •Persistent prosocial oxytocin effects were observed in adult C58/J mice.•Oxytocin increased sociability in C58/J up to 2 weeks following a subchronic regimen.•Subchronic oxytocin reversed overt social deficits in Grin1 knockdown mice.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Reversal of social deficits by subchronic oxytocin in two autism mouse models

Teng, Brian L. ; Nikolova, Viktoriya D. ; Riddick, Natallia V. ; Agster, Kara L. ; Crowley, James J. ; Baker, Lorinda K. ; Koller, Beverly H. ; Pedersen, Cort A. ; Jarstfer, Michael B. ; Moy, Sheryl S.

England: Elsevier Ltd

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