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The comparison of the humoral response among the patients with liver cirrhosis and steatosis of the liver after HBV vaccination

Koślińska-Berkan, Ewa ; Kuydowicz, Jan

Przegląd epidemiologiczny, 2006, Vol.60 (2), p.199 [Periódico revisado por pares]

Poland

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  • Título:
    The comparison of the humoral response among the patients with liver cirrhosis and steatosis of the liver after HBV vaccination
  • Autor: Koślińska-Berkan, Ewa ; Kuydowicz, Jan
  • Assuntos: Adult ; Aged ; Fatty Liver - immunology ; Female ; Hepatitis B Antibodies - blood ; Hepatitis B Surface Antigens - immunology ; Hepatitis B Vaccines - administration & dosage ; Humans ; Liver Cirrhosis - immunology ; Male ; Middle Aged ; Treatment Outcome ; Vaccines, Synthetic - administration & dosage
  • É parte de: Przegląd epidemiologiczny, 2006, Vol.60 (2), p.199
  • Descrição: The goal of the study was the assessment of the effectiveness of the hepatitis B vaccine among patients with liver diseases. Only those patients without serological markers for HBV infection (HBsAg-, anti-HBcT-, anti-HBs-) were selected. Twenty nine patients were vaccinated. The recombinant vaccine (Engerix-B SKB 20 microg) was used according to a 0, 1, 2 month regime. Serum samples for seroconversion rates and concentration of antiHBs were taken at month 1,2 and 3 after the first injection. The vaccines were divided into two groups. Group 1-16 patients with liver steatosis. Group 2-13 patients suffering from liver cirrhosis. The seroconversion rates and the concentrations of anti-HBs were taken at month 1,2 and 3 after the first injection. Good response to the HBV vaccine was observed in the patients with liver steatosis. 93, 7% of serocoversion to anty HB-s was observed after vaccination. The GMT of anti- HBs was 97,37 IU/l. Patients suffering from liver cirrhosis responded much less favorably to the hepatitis B vaccine than patients with liver steatosis. Seroconversion rate after third dose was 38,5%only, and GMT of anti-HBs was 18,48 IU/l. Patients suffering from the liver cirrhosis react much less favorably to the hepatitis B vaccine than patients with the liver steatosis.
  • Editor: Poland
  • Idioma: Polonês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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