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Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis

Wang, Qi ; Hu, Zhenquan ; Li, Xixiang ; Wang, Aoli ; Wu, Hong ; Liu, Jing ; Cao, Shugeng ; Liu, Qingsong

Journal of natural products (Washington, D.C.), 2018-11, Vol.81 (11), p.2531-2538 [Periódico revisado por pares]

United States: American Chemical Society and American Society of Pharmacognosy

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Título:
Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis
Autor: Wang, Qi ; Hu, Zhenquan ; Li, Xixiang ; Wang, Aoli ; Wu, Hong ; Liu, Jing ; Cao, Shugeng ; Liu, Qingsong
Assuntos: Cell Line, Tumor ; Cell Proliferation - drug effects ; Humans ; Medicine, Chinese Traditional ; Phenols - chemistry ; Phenols - pharmacology ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Salvia - chemistry
É parte de: Journal of natural products (Washington, D.C.), 2018-11, Vol.81 (11), p.2531-2538
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Six new phenolic acid derivatives, salviachinensines A–F (1–6), together with 14 known compounds (7–20) were isolated from the Chinese medicinal plant Salvia chinensis. The structures of salviachinensines A–F (1–6) were elucidated by NMR spectroscopy, bioinspired chemical synthesis, ECD analysis, and quantum chemical calculation methods. Compounds 2 and 3 are a pair of cis–trans isomers, and compounds 5 and 6 a pair of epimers. The solvent-induced isomerization of compounds 5 and 6 and the hypothetical biogenetic pathway of compounds 1–6, as well as the antiproliferative property and the ability of 1 to induce apoptosis and arrest cell cycle progression of MOLM-13 cells, were also investigated.
Editor: United States: American Chemical Society and American Society of Pharmacognosy
Idioma: Inglês

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Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis

Wang, Qi ; Hu, Zhenquan ; Li, Xixiang ; Wang, Aoli ; Wu, Hong ; Liu, Jing ; Cao, Shugeng ; Liu, Qingsong

United States: American Chemical Society and American Society of Pharmacognosy

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