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Complex networks of multiple factors in the pathogenesis of uterine leiomyoma

Islam, Md Soriful, Ph.D ; Protic, Olga, M.Sc ; Stortoni, Piergiorgio, M.D ; Grechi, Gianluca, M.D ; Lamanna, Pasquale, M.D ; Petraglia, Felice, M.D ; Castellucci, Mario, M.D., Ph.D ; Ciarmela, Pasquapina, Ph.D

Fertility and sterility, 2013-07, Vol.100 (1), p.178-193 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Complex networks of multiple factors in the pathogenesis of uterine leiomyoma
Autor: Islam, Md Soriful, Ph.D ; Protic, Olga, M.Sc ; Stortoni, Piergiorgio, M.D ; Grechi, Gianluca, M.D ; Lamanna, Pasquale, M.D ; Petraglia, Felice, M.D ; Castellucci, Mario, M.D., Ph.D ; Ciarmela, Pasquapina, Ph.D
Assuntos: angiogenesis ; Animals ; apoptosis ; Apoptosis - physiology ; cell proliferation ; chemokines ; DNA methylation ; Epigenesis, Genetic - physiology ; epigenetic factors ; epigenetics ; estrogens ; extracellular matrix ; Female ; fibroid ; genetic ; growth factors ; histones ; Humans ; Internal Medicine ; Leiomyoma - etiology ; Leiomyoma - genetics ; Leiomyoma - pathology ; mechanical stress ; microRNA ; Obstetrics and Gynecology ; pathogenesis ; patients ; Uterine leiomyoma ; Uterine Neoplasms - etiology ; Uterine Neoplasms - genetics ; Uterine Neoplasms - pathology
É parte de: Fertility and sterility, 2013-07, Vol.100 (1), p.178-193
Notas: http://dx.doi.org/10.1016/j.fertnstert.2013.03.007
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Objective To summarize the information regarding pathogenetic factors of leiomyoma formation and growth, and to make a simple integrated pathogenetic view of this tumor for further thinking to establish new therapeutic options. Design PubMed and Google Scholar searches were conducted to identify the relevant studies on pathogenesis of uterine leiomyoma, which are hereby reviewed and discussed. Setting Academic medical center. Patient(s) Not applicable. Intervention(s) Not applicable. Main Outcome Measure(s) Not applicable. Result(s) To date, the pathogenesis of uterine leiomyomas is not well understood. However, genetic alterations (especially MED12 and HMGA2 ) and involvement of epigenetic mechanisms (DNA methylation, histone modifications, and microRNA) in leiomyoma provide the clue of initiator of this tumor. Estrogens and P are considered as promoters of leiomyoma growth, and growth factors, cytokines, and chemokines are thought to be as potential effectors of estrogens and P. Extracellular matrix components are a major structural part of leiomyoma tissue that are abnormally orientated and can modify mechanical stress on cells, which leads to activation of internal mechanical signaling and may contribute to leiomyoma growth. Conclusion(s) Besides many genetics and epigenetic factors, the important link among the sex steroids, growth factors, cytokines, chemokines, and extracellular matrix and their involvement in cell proliferation, fibrotic processes, apoptosis, and angiogenesis are implicating a complex network in leiomyoma formation and growth. Those findings could provide information to establish future therapeutic options for the management of this tumor.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Complex networks of multiple factors in the pathogenesis of uterine leiomyoma

Islam, Md Soriful, Ph.D ; Protic, Olga, M.Sc ; Stortoni, Piergiorgio, M.D ; Grechi, Gianluca, M.D ; Lamanna, Pasquale, M.D ; Petraglia, Felice, M.D ; Castellucci, Mario, M.D., Ph.D ; Ciarmela, Pasquapina, Ph.D

United States: Elsevier Inc

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