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Neurostructural changes and declining sensorimotor function due to cerebellar cortical degeneration

Draganova, Rossitza ; Pfaffenrot, Viktor ; Steiner, Katharina M ; Göricke, Sophia L ; Elangovan, Naveen ; Timmann, Dagmar ; Konczak, Jürgen

Journal of neurophysiology, 2021-05, Vol.125 (5), p.1735-1745 [Periódico revisado por pares]

United States

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Título:
Neurostructural changes and declining sensorimotor function due to cerebellar cortical degeneration
Autor: Draganova, Rossitza ; Pfaffenrot, Viktor ; Steiner, Katharina M ; Göricke, Sophia L ; Elangovan, Naveen ; Timmann, Dagmar ; Konczak, Jürgen
Assuntos: Adult ; Aged ; Cerebellar Ataxia - diagnostic imaging ; Cerebellar Ataxia - pathology ; Cerebellar Ataxia - physiopathology ; Cerebellar Cortex - diagnostic imaging ; Cerebellar Cortex - pathology ; Cerebellar Cortex - physiopathology ; Cerebellar Nuclei - diagnostic imaging ; Cerebellar Nuclei - pathology ; Cerebellar Nuclei - physiopathology ; Female ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Gray Matter - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity - physiology ; Motor Cortex - physiopathology ; Psychomotor Performance - physiology
É parte de: Journal of neurophysiology, 2021-05, Vol.125 (5), p.1735-1745
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Neurodegeneration of the cerebellum progresses over years and primarily affects cerebellar cortex. It leads to a progressive loss of control and coordination of gait, posture, speech, fine motor, and oculomotor function. Yet, little is known how the cerebro-cerebellar network compensates for the loss in cerebellar cortical neurons. To address this knowledge gap, we examined 30 people with cerebellar cortical degeneration and a group of 30 healthy controls. We assessed visuomotor performance during a forearm-pointing task to 10°, 25°, and 50° targets. In addition, using MRI imaging, we determined neurodegenerative-induced changes in gray matter volume (GMV) in the cerebro-cerebellar network and correlated them to markers of motor performance. The main results are as follows: first, the relative joint position error (RJPE) during pointing was significantly greater in the ataxia group for all targets confirming the expected motor control deficit. Second, in the ataxia group, GMV was significantly reduced in cerebellar cortex but increased in the deep cerebellar nuclei. Motor error (RJPE) correlated negatively with decreased cerebellar GMV but positively with increased GMV in supplementary motor area (SMA) and premotor cortex. GMV of the deep cerebellar nuclei did not correlate significantly with markers of motor performance. We discuss whether the GMV changes in the cerebellar output nuclei and the extracerebellar efferent targets in secondary motor cortex can be understood as a central compensatory response to the neurodegeneration of the cerebellar cortex. Neurodegeneration of the cerebellum progresses over years and primarily affects cerebellar cortex. It leads to a progressive loss of control and coordination of movement. We here show that the neurodegenerative process not only leads to cells loss in cerebellar cortex but also induces neurostructural changes in the form of increased gray matter in the efferent targets of the cerebellar cortex, namely, the cerebellar output nuclei, the SMA, and premotor cortex.
Editor: United States
Idioma: Inglês

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Neurostructural changes and declining sensorimotor function due to cerebellar cortical degeneration

Draganova, Rossitza ; Pfaffenrot, Viktor ; Steiner, Katharina M ; Göricke, Sophia L ; Elangovan, Naveen ; Timmann, Dagmar ; Konczak, Jürgen

United States

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