skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

International benchmarking of childhood cancer survival by stage at diagnosis: The BENCHISTA project protocol

Botta, Laura ; Gatta, Gemma ; Didonè, Fabio ; Lopez Cortes, Angela ; Pritchard-Jones, Kathy Tiao, Gregory

PloS one, 2022-11, Vol.17 (11), p.e0276997-e0276997 [Periódico revisado por pares]

San Francisco, CA USA: Public Library of Science

Texto completo disponível

Citações Citado por
  • Título:
    International benchmarking of childhood cancer survival by stage at diagnosis: The BENCHISTA project protocol
  • Autor: Botta, Laura ; Gatta, Gemma ; Didonè, Fabio ; Lopez Cortes, Angela ; Pritchard-Jones, Kathy
  • Tiao, Gregory
  • Assuntos: Analysis ; Availability ; Benchmarks ; Bone cancer ; Cancer ; Cancer in children ; Children ; Data collection ; Data sources ; Datasets ; Diagnosis ; Ewings sarcoma ; Feasibility studies ; Guidelines ; International cooperation ; Kidney cancer ; Life Sciences ; Mathematical analysis ; Measuring instruments ; Medical diagnosis ; Medical prognosis ; Medical research ; Medicine, Experimental ; Medulloblastoma ; Morphology ; Neuroblastoma ; Osteosarcoma ; Patient outcomes ; Patients ; Pediatric research ; Pediatrics ; Population ; Prognosis ; Project feasibility ; Rhabdomyosarcoma ; Santé publique et épidémiologie ; Sarcoma ; Solid tumors ; Standardization ; Study Protocol ; Survival ; Survival analysis ; Tumor staging ; Tumors
  • É parte de: PloS one, 2022-11, Vol.17 (11), p.e0276997-e0276997
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Members of the BENCHISTA Project Working Group are mentioned in the Acknowledgments section.
    Competing Interests: The authors have declared that no competing interests exist.
    LB and GG share first authorship on this work.
  • Descrição: Several studies have shown significant variation in overall survival rates from childhood cancer between countries, using population-based cancer registry (PBCR) data for all cancers combined and for many individual tumour types among children. Without accurate and comparable data on Tumour stage at diagnosis, it is difficult to define the reasons for these survival differences. This is because measurement systems designed for adult cancers do not apply to children's cancers and cancer registries often hold limited information on paediatric tumour stage and the data sources used to define it. The BENCHISTA project aims to test the application of the international consensus "Toronto Staging Guidelines" (TG) for paediatric tumours by European and non-European PBCRs for six common paediatric solid tumours so that reliable comparisons of stage at diagnosis and survival rates by stage can be made to understand any differences. A secondary aim is to test the data availability and completeness of collection of several 'Toronto' consensus non-stage prognostic factors, treatment types given, occurrence of relapse/progression and cause of death as a descriptive feasibility study. PBCRs will use their permitted data access channels to apply the Toronto staging guidelines to all incident cases of six solid childhood cancers (medulloblastoma, osteosarcoma, Ewings sarcoma, rhabdomyosarcoma, neuroblastoma and Wilms tumour) diagnosed in a consecutive three-year period within 2014-2017 in their population. Each registry will provide a de-identified patient-level dataset including tumour stage at diagnosis, with only the contributing registry holding the information that would be needed to re-identify the patients. Where available to the registry, patient-level data on 'Toronto' non-stage prognostic factors, treatments given and clinical outcomes (relapse/progression/cause of death) will be included. More than 60 PBCRs have been involved in defining the patient-level dataset items and intend to participate by contributing their population-level data. Tumour-specific on-line training workshops with clinical experts are available to cancer registry staff to assist them in applying the Toronto staging guidelines in a consistent manner. There is also a project-specific help desk for discussion of difficult cases and promotion of the CanStaging online tools, developed through the International Association of Cancer Registries, to further ensure standardisation of data collection. Country-specific stage distribution and observed survival by stage at diagnosis will be calculated for each tumour type to compare survival between countries or large geographical regions. This study will be promote and enhance the collection of standardized staging data for childhood cancer by European and non-European population-based cancer registries. Therefore, this project can be seen as a feasibility project of widespread use of Toronto Staging at a population-level by cancer registries, specifying the data sources used and testing how well standardized the processes can be. Variation in tumour stage distribution could be due to real differences, to different diagnostic practices between countries and/or to variability in how cancer registries assign Toronto stage. This work also aims to strengthen working relationships between cancer registries, clinical services and cancer-specific clinical study groups, which is important for improving patient outcomes and stimulating research.
  • Editor: San Francisco, CA USA: Public Library of Science
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.