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The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters

de Wit, Emmie ; Prescott, Joseph ; Baseler, Laura ; Bushmaker, Trenton ; Thomas, Tina ; Lackemeyer, Matthew G ; Martellaro, Cynthia ; Milne-Price, Shauna ; Haddock, Elaine ; Haagmans, Bart L ; Feldmann, Heinz ; Munster, Vincent J Pyrc, Krzysztof

PloS one, 2013-07, Vol.8 (7), p.e69127-e69127 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters
Autor: de Wit, Emmie ; Prescott, Joseph ; Baseler, Laura ; Bushmaker, Trenton ; Thomas, Tina ; Lackemeyer, Matthew G ; Martellaro, Cynthia ; Milne-Price, Shauna ; Haddock, Elaine ; Haagmans, Bart L ; Feldmann, Heinz ; Munster, Vincent J
Pyrc, Krzysztof
Assuntos: Aerosols ; Analysis ; Animal diseases ; Animals ; Body Temperature - physiology ; Body Weight - physiology ; Coronaviridae ; Coronavirus - physiology ; Coronavirus Infections - virology ; Coronaviruses ; Cricetinae ; Dipeptidyl Peptidase 4 - metabolism ; Disease Models, Animal ; Disease transmission ; Fatalities ; Hamsters ; Host-Pathogen Interactions ; Humans ; Immunohistochemistry ; Infections ; Infectious diseases ; Inoculation ; Laboratory animals ; Lesions ; Mesocricetus - metabolism ; Mesocricetus - virology ; Mesocricetus auratus ; Middle East ; Middle East respiratory syndrome ; Pathogenesis ; Penicillin ; Physiological aspects ; Pneumonia ; Respiratory diseases ; Respiratory Tract Infections - virology ; Seroconversion ; Syndrome ; Trachea ; Virology ; Virus replication ; Virus Replication - physiology ; Viruses
É parte de: PloS one, 2013-07, Vol.8 (7), p.e69127-e69127
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: EdW HF VJM. Performed the experiments: EdW JP LB TB TT MGL CM SM-P EH VJM. Analyzed the data: EdW JP LB MGL SM-P EH VJM. Contributed reagents/materials/analysis tools: BLH. Wrote the manuscript: EdW HF VJM.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human transmission. The emergence of this novel coronavirus prompts the need for a small animal model to study the pathogenesis of this virus and to test the efficacy of potential intervention strategies. In this study we explored the use of Syrian hamsters as a small animal disease model, using intratracheal inoculation and inoculation via aerosol. Clinical signs of disease, virus replication, histological lesions, cytokine upregulation nor seroconversion were observed in any of the inoculated animals, indicating that MERS-CoV does not replicate in Syrian hamsters.
Editor: United States: Public Library of Science
Idioma: Inglês

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The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters

de Wit, Emmie ; Prescott, Joseph ; Baseler, Laura ; Bushmaker, Trenton ; Thomas, Tina ; Lackemeyer, Matthew G ; Martellaro, Cynthia ; Milne-Price, Shauna ; Haddock, Elaine ; Haagmans, Bart L ; Feldmann, Heinz ; Munster, Vincent J Pyrc, Krzysztof

United States: Public Library of Science

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