Idioma:

Analysis of the costs and cost-effectiveness of the guidelines recommended by the 2018 GESIDA/Spanish National AIDS Plan for initial antiretroviral therapy in HIV-infected adults

Pérez-Molina, José Antonio ; Martínez, Esteban ; Blasco, Antonio Javier ; Arribas, José Ramón ; Domingo, Pere ; Iribarren, José Antonio ; Knobel, Hernando ; Lázaro, Pablo ; López-Aldeguer, José ; Lozano, Fernando ; Mariño, Ana ; Miró, José M ; Moreno, Santiago ; Negredo, Eugenia ; Pulido, Federico ; Rubio, Rafael ; Santos, Jesús ; de la Torre, Javier ; Tuset, Montserrat ; von Wichmann, Miguel A ; Gatell, Josep M

Enfermedades infecciosas y microbiologia clinica, 2019-03, Vol.37 (3), p.151-159 [Periódico revisado por pares]

Spain: Elsevier España, S.L.U

Texto completo disponível

Citações Citado por

Enviar para

Título:
Analysis of the costs and cost-effectiveness of the guidelines recommended by the 2018 GESIDA/Spanish National AIDS Plan for initial antiretroviral therapy in HIV-infected adults
Autor: Pérez-Molina, José Antonio ; Martínez, Esteban ; Blasco, Antonio Javier ; Arribas, José Ramón ; Domingo, Pere ; Iribarren, José Antonio ; Knobel, Hernando ; Lázaro, Pablo ; López-Aldeguer, José ; Lozano, Fernando ; Mariño, Ana ; Miró, José M ; Moreno, Santiago ; Negredo, Eugenia ; Pulido, Federico ; Rubio, Rafael ; Santos, Jesús ; de la Torre, Javier ; Tuset, Montserrat ; von Wichmann, Miguel A ; Gatell, Josep M
Assuntos: AIDS ; Antiretroviral therapy ; Cost ; Costes ; effectiveness ; Efficiency ; Eficacia ; Eficiencia ; Human immunodeficiency virus ; Infectious Disease ; Sida ; Tratamiento antirretroviral ; Virus de inmunodeficiencia humana
É parte de: Enfermedades infecciosas y microbiologia clinica, 2019-03, Vol.37 (3), p.151-159
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Background The GESIDA/National AIDS Plan expert panel recommended preferred regimens (PR), alternative regimens (AR) and other regimens (OR) for antiretroviral treatment (ART) as initial therapy in HIV-infected patients for 2018. The objective of this study was to evaluate the costs and the efficiency of initiating treatment with PR and AR. Methods Economic assessment of costs and efficiency (cost-effectiveness) based on decision tree analyses. Effectiveness was defined as the probability of reporting a viral load <50 copies/mL at week 48, in an intention-to-treat analysis. Cost of initiating treatment with an ART regimen was defined as the costs of ART and its consequences (adverse effects, changes of ART regimen, and drug-resistance studies) over the first 48 weeks. The payer perspective (National Health System) was applied considering only differential direct costs: ART (official prices), management of adverse effects, studies of resistance, and HLA B*5701 testing. The setting was Spain and the costs correspond to those of 2018. A deterministic sensitivity analysis was conducted, building three scenarios for each regimen: base case, most favourable and least favourable. Results In the base-case scenario, the cost of initiating treatment ranges from 6788 euros for TAF/FTC/RPV (AR) to 10,649 euros for TAF/FTC + RAL (PR). The effectiveness varies from 0.82 for TAF/FTC + DRV/r (AR) to 0.91 for TAF/FTC + DTG (PR). The efficiency, in terms of cost-effectiveness, ranges from 7814 to 12,412 euros per responder at 48 weeks, for ABC/3TC/DTG (PR) and TAF/FTC + RAL (PR), respectively. Conclusion Considering ART official prices, the most efficient regimen was ABC/3TC/DTG (PR), followed by TAF/FTC/RPV (AR) and TAF/FTC/EVG/COBI (AR).
Editor: Spain: Elsevier España, S.L.U
Idioma: Inglês;Espanhol

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Analysis of the costs and cost-effectiveness of the guidelines recommended by the 2018 GESIDA/Spanish National AIDS Plan for initial antiretroviral therapy in HIV-infected adults

Spain: Elsevier España, S.L.U

Buscando em bases de dados remotas. Favor aguardar.