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Vitamin K intake and hip fractures in women: a prospective study

Feskanich, D ; Weber, P ; Willett, W.C ; Rockett, H ; Booth, S.L ; Colditz, G.A

The American journal of clinical nutrition, 1999, Vol.69 (1), p.74-79 [Periódico revisado por pares]

Bethesda, MD: American Society for Clinical Nutrition

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Título:
Vitamin K intake and hip fractures in women: a prospective study
Autor: Feskanich, D ; Weber, P ; Willett, W.C ; Rockett, H ; Booth, S.L ; Colditz, G.A
Assuntos: Adult ; Analysis of Variance ; Biological and medical sciences ; Body Mass Index ; bone fractures ; Cohort Studies ; Diet ; Diseases of the osteoarticular system ; estrogens ; Female ; food intake ; foods ; Fractures ; Hip Fractures - prevention & control ; Hip joint ; hormone supplements ; Humans ; Massachusetts ; Medical sciences ; Middle Aged ; nurses health study ; nutrient intake ; Osteoporosis ; Osteoporosis. Osteomalacia. Paget disease ; Prospective Studies ; risk ; Surveys and Questionnaires ; vitamin K ; Vitamin K - administration & dosage ; Vitamin K - therapeutic use ; Vitamins ; Women
É parte de: The American journal of clinical nutrition, 1999, Vol.69 (1), p.74-79
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background: Vitamin K mediates the gamma-carboxylation of glutamyl residues on several bone proteins, notably osteocalcin. High serum concentrations of undercarboxylated osteocalcin and low serum concentrations of vitamin K are associated with lower bone mineral density and increased risk of hip fracture. However, data are limited on the effects of dietary vitamin K. Objective: We investigated the hypothesis that high intakes of vitamin K are associated with a lower risk of hip fracture in women. Design: We conducted a prospective analysis within the Nurses' Health Study cohort. Diet was assessed in 72327 women aged 38-63 y with a food-frequency questionnaire in 1984 (baseline). During the subsequent 10 y of follow-up, 270 hip fractures resulting from low or moderate trauma were reported. Results: Women in quintiles 2-5 of vitamin K intake had a significantly lower age-adjusted relative risk (RR: 0.70; 95% CI: 0.53, 0.93) of hip fracture than women in the lowest quintile (< 109 microgram/d). Risk did not decrease between quintiles 2 and 5 and risk estimates were not altered when other risk factors for osteoporosis, including calcium and vitamin D intakes, were added to the models. Risk of hip fracture was also inversely associated with lettuce consumption (RR: 0.55; 95% CI: 0.40, 0.78) for one or more servings per day compared with one or fewer servings per week), the food that contributed the most to dietary vitamin K intakes. Conclusions: Low intakes of vitamin K may increase the risk of hip fracture in women. The data support the suggestion for a reassessment of the vitamin K requirements that are based on bone health and blood coagulation.
Editor: Bethesda, MD: American Society for Clinical Nutrition
Idioma: Inglês

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Vitamin K intake and hip fractures in women: a prospective study

Feskanich, D ; Weber, P ; Willett, W.C ; Rockett, H ; Booth, S.L ; Colditz, G.A

Bethesda, MD: American Society for Clinical Nutrition

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