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The Effectiveness of Fish Oil Supplementation in Asthmatic Rats is Limited by an Inefficient Action on ASM Function

Miranda, D. T. S. Z. ; Zanatta, A. L. ; Dias, B. C. L. ; Fogaça, R. T. H. ; Maurer, J. B. B. ; Donatti, L. ; Calder, P. C. ; Nishiyama, A.

Lipids, 2013-09, Vol.48 (9), p.889-897 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
The Effectiveness of Fish Oil Supplementation in Asthmatic Rats is Limited by an Inefficient Action on ASM Function
Autor: Miranda, D. T. S. Z. ; Zanatta, A. L. ; Dias, B. C. L. ; Fogaça, R. T. H. ; Maurer, J. B. B. ; Donatti, L. ; Calder, P. C. ; Nishiyama, A.
Assuntos: Acetylcholine - pharmacology ; Airway smooth muscle ; Analysis of Variance ; Animals ; Asthma ; Asthma - chemically induced ; Asthma - physiopathology ; Biomedical and Life Sciences ; Bronchoalveolar Lavage Fluid - cytology ; Bronchodilator Agents - pharmacology ; Cytokine ; Dietary Supplements ; Eosinophils - drug effects ; Eosinophils - pathology ; Fish oil ; Fish Oils - administration & dosage ; Fish Oils - pharmacology ; In Vitro Techniques ; Inflammation ; Interleukin-1beta - metabolism ; Isoproterenol - pharmacology ; Life Sciences ; Lipidology ; Lung - drug effects ; Lung - metabolism ; Lung - pathology ; Lung Compliance - drug effects ; Lymphocytes - drug effects ; Lymphocytes - pathology ; Macrophages - drug effects ; Macrophages - pathology ; Male ; Medical Biochemistry ; Medicinal Chemistry ; Microbial Genetics and Genomics ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiopathology ; Neurochemistry ; Neutrophils - drug effects ; Neutrophils - pathology ; Nutrition ; n‐3 Fatty acids ; Original Article ; Ovalbumin ; Rats ; Rats, Wistar ; Trachea - drug effects ; Trachea - physiopathology ; Tumor Necrosis Factor-alpha - metabolism ; Vasodilator Agents - pharmacology
É parte de: Lipids, 2013-09, Vol.48 (9), p.889-897
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Episodes of acute exacerbation are the major clinical feature of asthma and therefore represent an important focus for developing novel therapies for this disease. There are many reports that the n-3 fatty acids found in fish oil exert anti-inflammatory effects, but there are few studies of the action of fish oil on airway smooth muscle (ASM) function. In the present investigation, we evaluated the effect of fish oil supplementation on smooth muscle force of contraction in ovalbumin-induced asthmatic Wistar rats, and its consequences on static lung compliance, mucus production, leukocyte chemotaxis and production of proinflammatory cytokines. Fish oil supplementation suppressed the infiltration of inflammatory cells into the lung in asthmatic animals (2.04 ± 0.19 × 10 6 cells vs. 3.33 ± 0.43 × 10 6 cells in the control asthmatic group; P < 0.05). Static lung compliance increased with fish oil supplementation in asthmatic rats (0.640 ± 0.053 mL/cm H 2 O vs. 0.399 ± 0.043 mL/cm H 2 O; P < 0.05). However, fish oil did not prevent asthma-associated lung eosinophilia and did not affect the concentrations of tumor necrosis factor-α and interleukin-1β in lung tissue or the proportion of the airways obliterated with mucus. Fish oil had no effect on the force of contraction in asthmatic rats in response to acetylcholine (3.026 ± 0.274 mN vs. 2.813 ± 0.364 mN in the control asthmatic group). In conclusion, although fish oil exerts some benefits in this model of asthma, its effectiveness appears to be limited by an inefficient action on airway smooth muscle function.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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The Effectiveness of Fish Oil Supplementation in Asthmatic Rats is Limited by an Inefficient Action on ASM Function

Miranda, D. T. S. Z. ; Zanatta, A. L. ; Dias, B. C. L. ; Fogaça, R. T. H. ; Maurer, J. B. B. ; Donatti, L. ; Calder, P. C. ; Nishiyama, A.

Berlin/Heidelberg: Springer Berlin Heidelberg

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