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Differential survival of Brazilian patients with diffuse large B-cell lymphoma with and without HIV infection

Ferreira, Mariana P ; Thuler, Luiz Claudio S ; Bergmann, Anke ; Soares, Esmeralda A ; Soares, Marcelo A

AIDS (London), 2023-12, Vol.37 (15), p.2331-2338 [Periódico revisado por pares]

England

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  • Título:
    Differential survival of Brazilian patients with diffuse large B-cell lymphoma with and without HIV infection
  • Autor: Ferreira, Mariana P ; Thuler, Luiz Claudio S ; Bergmann, Anke ; Soares, Esmeralda A ; Soares, Marcelo A
  • Assuntos: Brazil - epidemiology ; Case-Control Studies ; HIV Infections - complications ; HIV Infections - drug therapy ; Humans ; Lymphoma, Large B-Cell, Diffuse - complications ; Lymphoma, Large B-Cell, Diffuse - drug therapy ; Lymphoma, Non-Hodgkin ; Prognosis ; Retrospective Studies
  • É parte de: AIDS (London), 2023-12, Vol.37 (15), p.2331-2338
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Combinatorial antiretroviral therapy provided improvement of HIV patients' immune function and a decrease in the incidence of non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is one of the most common NHL forms affecting HIV+ patients. The present study aimed to evaluate the impact of HIV infection on the prognosis of patients treated for DLBCL in a reference cancer treatment center in Brazil. A retrospective case-control study was developed with patients followed-up at the Brazilian National Cancer Institute, in which 243 DLBCL patients (91 HIV+ and 152 HIV-) were enrolled. HIV- controls were matched to HIV+ according to date of cancer diagnosis, clinical staging, primary cancer treatment and date of birth. Sociodemographic and cancer treatment data were extracted from medical charts. Kaplan-Meier analyses were carried out to estimate survival, while univariate and multiple Cox regression analyses were used to determine factors associated with mortality. A total of 98 deaths were observed in a 5-year period after cancer diagnosis. A negative association of HIV infection with both overall and disease-specific survival 1 year after cancer diagnosis was observed [hazard ratio (HR) = 1.98 and 1.96, respectively]. The negative association with HIV infection with disease-specific survival remained significant for a 5-year period after cancer diagnosis (HR = 1.53). HIV viral load above 1000 copies/ml at study entry was also associated with shorter overall and cancer-specific survival. HIV infection negatively impacted prognosis and mortality of DLBCL patients irrespective of cancer-related clinical factors.
  • Editor: England
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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