Idioma:

Windkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study

Behnam, Vira ; Rong, Jian ; Larson, Martin G ; Gotal, John D ; Benjamin, Emelia J ; Hamburg, Naomi M ; Vasan, Ramachandran S ; Mitchell, Gary F

Journal of the American Heart Association, 2019-07, Vol.8 (14), p.e012300-e012300 [Periódico revisado por pares]

England: John Wiley and Sons Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Windkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study
Autor: Behnam, Vira ; Rong, Jian ; Larson, Martin G ; Gotal, John D ; Benjamin, Emelia J ; Hamburg, Naomi M ; Vasan, Ramachandran S ; Mitchell, Gary F
Assuntos: Aged ; Arterial Pressure ; arterial stiffness ; Blood Pressure ; Carotid Arteries - physiopathology ; Female ; Heart Failure - epidemiology ; Heart Rate ; Humans ; Longitudinal Studies ; Male ; Manometry ; Middle Aged ; Myocardial Infarction - epidemiology ; Myocardial Infarction - mortality ; Nonlinear Dynamics ; Original Research ; pressure waveform analysis ; Proportional Hazards Models ; Pulse Wave Analysis ; Risk Assessment ; Stroke - epidemiology ; tau ; Windkessel
É parte de: Journal of the American Heart Association, 2019-07, Vol.8 (14), p.e012300-e012300
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Background Waveform parameters derived from pressure-only Windkessel models are related to cardiovascular disease risk and could be useful for understanding arterial system function. However, prior reports varied in their adjustment for potential confounders. Methods and Results Carotid tonometry waveform data from 2539 participants (mean age 63±11 years, 58% women) of the Framingham Heart Study were used to derive Windkessel measures using pressure and assuming a linear model with fixed diastolic time constant (τ ) and variable asymptotic pressure (P , median 54.5; 25th, 75th percentiles: 38.4, 64.9 mm Hg) or nonlinear model with inverse pressure-dependent τ and fixed P (20 mm Hg). During follow-up (median 15.1 years), 459 (18%) participants had a first cardiovascular disease event. In proportional hazards models adjusted for age, sex, total cholesterol, high-density lipoprotein cholesterol, smoking, antihypertensive medication use, diabetes mellitus, and physician-acquired systolic blood pressure, only the systolic time constant (τ ) derived from the nonlinear model was related to risk for cardiovascular disease events (hazard ratio=0.91 per 1 SD, 95% CI=0.84-0.99, P=0.04). When heart rate was added to the model, τ (hazard ratio=0.92, CI=0.84-1.00, P=0.04) and reservoir pressure amplitude (hazard ratio=1.14, CI=1.01-1.28, P=0.04) were related to events. In contrast, measures derived from the linear model were not related to events in models that adjusted for risk factors including systolic blood pressure ( P>0.31) and heart rate ( P>0.19). Conclusions Our results suggest that pressure-only Windkessel measures derived by using a nonlinear model may provide incremental risk stratification, although associations were modest and further validation is required.
Editor: England: John Wiley and Sons Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Windkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study

Behnam, Vira ; Rong, Jian ; Larson, Martin G ; Gotal, John D ; Benjamin, Emelia J ; Hamburg, Naomi M ; Vasan, Ramachandran S ; Mitchell, Gary F

England: John Wiley and Sons Inc

Buscando em bases de dados remotas. Favor aguardar.