Idioma:

Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes

Lee, Anna ; Choi, Kyeong-Mi ; Jung, Won-Beom ; Jeong, Heejin ; Kim, Ga-Yeong ; Lee, Ju Hyun ; Lee, Mi Kyeong ; Hong, Jin Tae ; Roh, Yoon-Seok ; Sung, Sang-Hyun ; Yoo, Hwan-Soo

Molecules (Basel, Switzerland), 2017-08, Vol.22 (9), p.1423 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por

Enviar para

Título:
Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes
Autor: Lee, Anna ; Choi, Kyeong-Mi ; Jung, Won-Beom ; Jeong, Heejin ; Kim, Ga-Yeong ; Lee, Ju Hyun ; Lee, Mi Kyeong ; Hong, Jin Tae ; Roh, Yoon-Seok ; Sung, Sang-Hyun ; Yoo, Hwan-Soo
Assuntos: 3T3-L1 Cells ; Acids ; adipocyte differentiation ; Adipocytes ; Adipocytes - cytology ; Adipocytes - drug effects ; Adipocytes - metabolism ; Adipogenesis ; Animals ; CCAAT/enhancer-binding protein ; Communication ; Diabetes mellitus ; Glucose ; Glucose - metabolism ; Glucose transporter ; Glucose Transporter Type 4 - metabolism ; glucose uptake ; GLUT4 ; Guaiacol - analogs & derivatives ; Guaiacol - pharmacology ; Insulin ; Insulin resistance ; Lignans - pharmacology ; meso-dihydroguaiaretic acid ; Mice ; PPAR gamma - metabolism ; Sensitivity enhancement ; Signal transduction ; Translocation ; type 2 diabetes mellitus ; Up-Regulation
É parte de: Molecules (Basel, Switzerland), 2017-08, Vol.22 (9), p.1423
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
Descrição: Type 2 diabetes is characterized by insulin resistance, which leads to increased blood glucose levels. Adipocytes are involved in the development of insulin resistance, resulting from the dysfunction of the insulin signaling pathway. In this study, we investigated whether -dihydroguaiaretic acid (MDGA) may modulate glucose uptake in adipocytes, and examined its mechanism of action. MDGA enhanced adipogenesis through up-regulation of peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding protein α in 3T3-L1 adipocytes partially differentiated with sub-optimal concentrations of insulin. MDGA also increased glucose uptake by stimulating expression and translocation of glucose transporter 4 (GLUT4) in adipocytes. These results suggest that MDGA may increase GLUT4 expression and its translocation by promoting insulin sensitivity, leading to enhanced glucose uptake.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes

Lee, Anna ; Choi, Kyeong-Mi ; Jung, Won-Beom ; Jeong, Heejin ; Kim, Ga-Yeong ; Lee, Ju Hyun ; Lee, Mi Kyeong ; Hong, Jin Tae ; Roh, Yoon-Seok ; Sung, Sang-Hyun ; Yoo, Hwan-Soo

Switzerland: MDPI AG

Buscando em bases de dados remotas. Favor aguardar.