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Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital

Kishii, Kozue ; Ito, Teruyo ; Watanabe, Shinya ; Okuzumi, Katsuko ; Hiramatsu, Keiichi

Journal of antimicrobial chemotherapy, 2008-08, Vol.62 (2), p.324-328 [Periódico revisado por pares]

Oxford: Oxford University Press

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Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital
Autor: Kishii, Kozue ; Ito, Teruyo ; Watanabe, Shinya ; Okuzumi, Katsuko ; Hiramatsu, Keiichi
Assuntos: Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Bacterial Typing Techniques ; Biological and medical sciences ; community-associated MRSA ; Cross Infection - microbiology ; DNA, Bacterial - genetics ; Drug resistance ; Genes, Bacterial ; Genotype ; Genotype & phenotype ; healthcare-associated MRSA ; Hospitals ; Hospitals, University ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Methicillin Resistance ; Microbial Sensitivity Tests ; Microbiology ; Molecular Epidemiology ; Molecular Sequence Data ; Pharmacology. Drug treatments ; population analysis ; Sequence Analysis, DNA ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification ; Staphylococcus infections ; Tokyo ; β-lactam antibiotics
É parte de: Journal of antimicrobial chemotherapy, 2008-08, Vol.62 (2), p.324-328
Notas: istex:101D977FBDD5D5B3BE94773AA2B6C2B7865F50F6
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Descrição: Objectives In the early 1980s, heterogeneous methicillin-resistant Staphylococcus aureus (hetero-MRSA) strains were predominant in the University of Tokyo Hospital. But, in the 1990s, they were completely substituted by homogeneously highly methicillin-resistant S. aureus (homo-MRSA) strains. Since 2000, however, we started observing an increase in MRSA strains with low cefazolin MICs (MRCLSA). This study was performed to understand the phenomenon by characterization of the ‘cefazolin-susceptible’ MRSA strains. Methods A total of 39 MRCLSA strains were collected between July 2000 and June 2002 and compared with 10 homo-MRSA strains isolated during the same period for their antibiograms and genotypes. The strains were also compared with the hetero-MRSA strains isolated in the same hospital in the early 1980s. Results In contrast to the homogeneous genotype [multilocus sequence type 5 and SCCmec type II.1 (IIa)] and multiresistant nature of the homo-MRSA strains, the MRCLSA strains were composed of various genotypes as revealed by multilocus sequence typing and SCCmec typing and had resistance only to a limited number of antibiotics. Most of the MRCLSA strains were also genetically differentiated from the hetero-MRSA strains of the 1980s. However, population analysis revealed that all of the MRCLSA strains were classified as hetero-MRSA strains. Conclusions A new group of hetero-MRSA strains genetically distinct from those dominant in the same hospital in the early 1980s might have emerged in the community and started invading the university hospital. This phenomenon may be caused by the change in the pattern of antibiotic use.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital

Kishii, Kozue ; Ito, Teruyo ; Watanabe, Shinya ; Okuzumi, Katsuko ; Hiramatsu, Keiichi

Oxford: Oxford University Press

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