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Radiolabelling of a lung cancer-targeting small molecule polypeptide with (131)I and its radioactivity distribution in normal rabbits

Zheng, Wenli ; Li, Guiping ; Huang, Baodan ; DU, Li ; Huang, Kai

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014-08, Vol.34 (9), p.1375-1379

China

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  • Título:
    Radiolabelling of a lung cancer-targeting small molecule polypeptide with (131)I and its radioactivity distribution in normal rabbits
  • Autor: Zheng, Wenli ; Li, Guiping ; Huang, Baodan ; DU, Li ; Huang, Kai
  • Assuntos: Animals ; Antineoplastic Agents - pharmacokinetics ; Chloramines ; Humans ; Iodine Radioisotopes - chemistry ; Lung Neoplasms ; Male ; Peptides - pharmacokinetics ; Rabbits ; Radiopharmaceuticals - pharmacokinetics ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon ; Tosyl Compounds
  • É parte de: Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014-08, Vol.34 (9), p.1375-1379
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: To establish a labeling method for a specific lung cancer-targeting small molecule peptide cNGQGEQc with ¹³¹I and observe the radioactivity distribution of the labeled peptide in rabbits using single-photon emission computed tomography (SPECT). Chloramine-T method was used for ¹³¹I labeling of the tyrosine amino group on cNGQGEQc, and the labeling efficiency and radiochemical purity of ¹³¹I-cNGQGEQc were determined with paper chromatography. The stability of ¹³¹I-cNGQGEQc in saline and human serum was assessed after incubation in water bath at 37 degrees celsius; for 24 h. The octanol-water partition coefficient lg P (the radioactivity counting ratio of ¹³¹I-cNGQGEQc dissolved in 100 µl octanol or in 100 µl saline) was calculated. SPECT was performed in 3 male New Zealand white rabbits after intravenous injection of ¹³¹I-cNGQGEQc to observe the dynamic distribution of the peptide with the time-radioactivity curve (T-A curve) of the region of interest (ROI). With a labeling efficiency of 90%, ¹³¹I-cNGQGEQc sho
  • Editor: China
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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