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The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis

Taniue, Kenzui ; Akimitsu, Nobuyoshi

International journal of molecular sciences, 2021-01, Vol.22 (2), p.632 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis
Autor: Taniue, Kenzui ; Akimitsu, Nobuyoshi
Assuntos: Animals ; Biosynthesis ; Cancer ; Cell cycle ; Deoxyribonucleic acid ; Diagnostic systems ; DNA ; dysregulation of lncRNA expression ; Gene Expression Regulation, Neoplastic ; Genes ; Genomes ; Homeostasis ; Humans ; lncRNA-protein interactions ; long noncoding RNAs (lncRNAs) ; Macromolecules ; Molecular modelling ; Neoplasms - etiology ; Neoplasms - genetics ; Neoplasms - metabolism ; Nucleotides ; oncogenic lncRNA ; Phenotypes ; Proteins ; Review ; RNA polymerase ; RNA, Long Noncoding - metabolism ; subcellular localization ; tumor suppressive lncRNAs ; Tumorigenesis
É parte de: International journal of molecular sciences, 2021-01, Vol.22 (2), p.632
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Over the past decades, research on cancer biology has focused on the involvement of protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are transcripts longer than 200 nucleotides that lack protein-coding potential, are an important class of RNA molecules that are involved in a variety of biological functions. Although the functions of a majority of lncRNAs have yet to be clarified, some lncRNAs have been shown to be associated with human diseases such as cancer. LncRNAs have been shown to contribute to many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein and RNA. Here we describe the literature regarding the biogenesis and features of lncRNAs. We also present an overview of the current knowledge regarding the roles of lncRNAs in cancer from the view of various aspects of cellular homeostasis, including proliferation, survival, migration and genomic stability. Furthermore, we discuss the methodologies used to identify the function of lncRNAs in cancer development and tumorigenesis. Better understanding of the molecular mechanisms involving lncRNA functions in cancer is critical for the development of diagnostic and therapeutic strategies against tumorigenesis.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis

Taniue, Kenzui ; Akimitsu, Nobuyoshi

Switzerland: MDPI AG

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