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Validating a Markov Model of Treatment for Hepatitis C Virus-related Hepatocellular Carcinoma

Ishida, H. ; Wong, J.B. ; Hino, K. ; Kurokawa, F. ; Nishina, S. ; Sakaida, I. ; Okita, K. ; Tamesa, T. ; Oka, M. ; Torimura, T. ; Sata, M. ; Takahash, S. ; Chayama, K. ; Inoue, Y.

Methods of information in medicine, 2008-01, Vol.47 (6), p.529-540 [Periódico revisado por pares]

Germany: Schattauer Verlag für Medizin und Naturwissenschaften

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Título:
Validating a Markov Model of Treatment for Hepatitis C Virus-related Hepatocellular Carcinoma
Autor: Ishida, H. ; Wong, J.B. ; Hino, K. ; Kurokawa, F. ; Nishina, S. ; Sakaida, I. ; Okita, K. ; Tamesa, T. ; Oka, M. ; Torimura, T. ; Sata, M. ; Takahash, S. ; Chayama, K. ; Inoue, Y.
Assuntos: Aged ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - economics ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - physiopathology ; Confidence Intervals ; Cost-Benefit Analysis ; Disease Progression ; Female ; Hepatitis C - complications ; Hepatitis C - drug therapy ; Hepatitis C - economics ; Hepatitis C - mortality ; Hepatocellular carcinoma ; Humans ; Male ; Markov Chains ; Markov model ; Middle Aged ; Models, Statistical ; Original Article ; Probability ; Prognosis ; Retrospective Studies ; Survival ; survival rate ; Validation
É parte de: Methods of information in medicine, 2008-01, Vol.47 (6), p.529-540
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Objective: We created and validated a Markov model to simulate the prognosis with treatment for HCV-related hepatocellular carcinoma (HCC) for assessment of cost-effectiveness for alternative treatments of HCC. Method: Markov state incorporated into the model consisted of the treatment as a surrogate for HCC stage and underlying liver function. Retrospective data of 793 patients from three university hospitals were used to determine Kaplan-Meier survival curves for each treatment and transition probabilities were derived from them. Results: There was substantial overlap in the 95% CIs of the Markov model predicted and the Kaplan-Meier survival curves for each therapy. The predicted survival curves were also similar with those from the nationwide survey data supporting the external validity of our model. Conclusions: Our Markov model estimates for prognosis with HCC have both internal and external validity and should be considered applicable for estimating cost-effectiveness related to HCC.
Editor: Germany: Schattauer Verlag für Medizin und Naturwissenschaften
Idioma: Inglês;Alemão

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Validating a Markov Model of Treatment for Hepatitis C Virus-related Hepatocellular Carcinoma

Ishida, H. ; Wong, J.B. ; Hino, K. ; Kurokawa, F. ; Nishina, S. ; Sakaida, I. ; Okita, K. ; Tamesa, T. ; Oka, M. ; Torimura, T. ; Sata, M. ; Takahash, S. ; Chayama, K. ; Inoue, Y.

Germany: Schattauer Verlag für Medizin und Naturwissenschaften

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