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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Garrett-Bakelman, Francine E ; Darshi, Manjula ; Green, Stefan J ; Gur, Ruben C ; Lin, Ling ; Macias, Brandon R ; McKenna, Miles J ; Meydan, Cem ; Mishra, Tejaswini ; Nasrini, Jad ; Piening, Brian D ; Rizzardi, Lindsay F ; Sharma, Kumar ; Siamwala, Jamila H ; Taylor, Lynn ; Vitaterna, Martha Hotz ; Afkarian, Maryam ; Afshinnekoo, Ebrahim ; Ahadi, Sara ; Ambati, Aditya ; Arya, Maneesh ; Bezdan, Daniela ; Callahan, Colin M ; Chen, Songjie ; Choi, Augustine M K ; Chlipala, George E ; Contrepois, Kévin ; Covington, Marisa ; Crucian, Brian E ; De Vivo, Immaculata ; Dinges, David F ; Ebert, Douglas J ; Feinberg, Jason I ; Gandara, Jorge A ; George, Kerry A ; Goutsias, John ; Grills, George S ; Hargens, Alan R ; Heer, Martina ; Hillary, Ryan P ; Hoofnagle, Andrew N ; Hook, Vivian Y H ; Jenkinson, Garrett ; Jiang, Peng ; Keshavarzian, Ali ; Laurie, Steven S ; Lee-McMullen, Brittany ; Lumpkins, Sarah B ; MacKay, Matthew ; Maienschein-Cline, Mark G ; Melnick, Ari M ; Moore, Tyler M ; Nakahira, Kiichi ; Patel, Hemal H ; Pietrzyk, Robert ; Rao, Varsha ; Saito, Rintaro ; Salins, Denis N ; Schilling, Jan M ; Sears, Dorothy D ; Sheridan, Caroline K ; Stenger, Michael B ; Tryggvadottir, Rakel ; Urban, Alexander E ; Vaisar, Tomas ; Van Espen, Benjamin ; Zhang, Jing ; Ziegler, Michael G ; Zwart, Sara R ; Charles, John B ; Kundrot, Craig E ; Scott, Graham B I ; Bailey, Susan M ; Basner, Mathias ; Feinberg, Andrew P ; Lee, Stuart M C ; Mason, Christopher E ; Mignot, Emmanuel ; Rana, Brinda K ; Smith, Scott M ; Snyder, Michael P ; Turek, Fred W

Science (American Association for the Advancement of Science), 2019-04, Vol.364 (6436) [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
Autor: Garrett-Bakelman, Francine E ; Darshi, Manjula ; Green, Stefan J ; Gur, Ruben C ; Lin, Ling ; Macias, Brandon R ; McKenna, Miles J ; Meydan, Cem ; Mishra, Tejaswini ; Nasrini, Jad ; Piening, Brian D ; Rizzardi, Lindsay F ; Sharma, Kumar ; Siamwala, Jamila H ; Taylor, Lynn ; Vitaterna, Martha Hotz ; Afkarian, Maryam ; Afshinnekoo, Ebrahim ; Ahadi, Sara ; Ambati, Aditya ; Arya, Maneesh ; Bezdan, Daniela ; Callahan, Colin M ; Chen, Songjie ; Choi, Augustine M K ; Chlipala, George E ; Contrepois, Kévin ; Covington, Marisa ; Crucian, Brian E ; De Vivo, Immaculata ; Dinges, David F ; Ebert, Douglas J ; Feinberg, Jason I ; Gandara, Jorge A ; George, Kerry A ; Goutsias, John ; Grills, George S ; Hargens, Alan R ; Heer, Martina ; Hillary, Ryan P ; Hoofnagle, Andrew N ; Hook, Vivian Y H ; Jenkinson, Garrett ; Jiang, Peng ; Keshavarzian, Ali ; Laurie, Steven S ; Lee-McMullen, Brittany ; Lumpkins, Sarah B ; MacKay, Matthew ; Maienschein-Cline, Mark G ; Melnick, Ari M ; Moore, Tyler M ; Nakahira, Kiichi ; Patel, Hemal H ; Pietrzyk, Robert ; Rao, Varsha ; Saito, Rintaro ; Salins, Denis N ; Schilling, Jan M ; Sears, Dorothy D ; Sheridan, Caroline K ; Stenger, Michael B ; Tryggvadottir, Rakel ; Urban, Alexander E ; Vaisar, Tomas ; Van Espen, Benjamin ; Zhang, Jing ; Ziegler, Michael G ; Zwart, Sara R ; Charles, John B ; Kundrot, Craig E ; Scott, Graham B I ; Bailey, Susan M ; Basner, Mathias ; Feinberg, Andrew P ; Lee, Stuart M C ; Mason, Christopher E ; Mignot, Emmanuel ; Rana, Brinda K ; Smith, Scott M ; Snyder, Michael P ; Turek, Fred W
Assuntos: Adaptation, Physiological ; Adaptive Immunity ; Aerospace environments ; Aging ; Astronauts ; Body Composition ; Body mass ; Body size ; Body Weight ; Bone density ; Brain ; Carotid arteries ; Carotid Arteries - diagnostic imaging ; Carotid artery ; Carotid Intima-Media Thickness ; Cognitive ability ; Cytokines ; Deoxyribonucleic acid ; Distension ; DNA ; DNA Damage ; DNA Methylation ; Earth environment ; Elongation ; Environment ; Environmental stress ; Epigenetics ; Gastrointestinal Microbiome ; Gene expression ; Gene regulation ; Genomes ; Genomic Instability ; Health risks ; Human performance ; Humans ; Immune response ; Immune system ; International Space Station ; Intestinal microflora ; Lymphocytes T ; Male ; Manned space flight ; Mars ; Metabolites ; Metabolomics ; Microbiomes ; Microgravity ; Microorganisms ; Oxidative stress ; Physiological effects ; Physiology ; Proteomics ; Radiation ; Retina ; Return to Earth space flight ; Risk factors ; Scientific Concepts ; Space Exploration ; Space Flight ; Space habitats ; Space missions ; Space stations ; Spacecraft components ; T cell receptors ; Telomerase ; Telomere Homeostasis ; Thickness ; Time Factors ; Transcription ; United States ; United States National Aeronautics and Space Administration ; Vaccination
É parte de: Science (American Association for the Advancement of Science), 2019-04, Vol.364 (6436)
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
Present address: HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Present address: IUBH International University of Applied Sciences, Bad Reichenhall, Germany.
Present address: Providence Portland Medical Center, Portland, OR, USA.
Present address: Augusta University, Augusta, GA, USA.
Present address: Nara Medical University, Nara, Japan.
Present address: Brown University, Providence, RI, USA.
Present address: Mayo Clinic, Rochester, MN, USA.
Present address: Institute for Advanced Biosciences, Keio University, Tokyo, Japan.
Descrição: To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

United States: The American Association for the Advancement of Science

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