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An investigation of the teratogenic potential of captan, folpet, and Difolatan

Kennedy, Gerald ; Fancher, Otis E. ; Calandra, J.C.

Toxicology and applied pharmacology, 1968-11, Vol.13 (3), p.420-430 [Periódico revisado por pares]

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Título:
An investigation of the teratogenic potential of captan, folpet, and Difolatan
Autor: Kennedy, Gerald ; Fancher, Otis E. ; Calandra, J.C.
Assuntos: Abnormalities, Drug-Induced - epidemiology ; Animal Feed ; Animals ; Antifungal Agents - pharmacology ; Birth Weight ; Body Weight ; Cricetinae ; Female ; Pregnancy ; Pregnancy, Animal ; Rabbits
É parte de: Toxicology and applied pharmacology, 1968-11, Vol.13 (3), p.420-430
Descrição: Three fungicides, captan, folpet, and Difolatan, were found to be nonteratogenic in two strains of rabbits that were particularly sensitive to the embryotoxic effects of thalidomide. Two metabolic products, phthalimide and tetrahydrophthalimide were also found to be nonteratogenic in the Dutch Belted rabbit. Offspring of albino rats, given the fungicides either during gestation only or over three consecutive generations, were free of abnormalities. Captan administered to the hamster throughout gestation did not produce abnormal young.
Editor: United States: Elsevier Inc
Idioma: Inglês

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