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How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?

Yuan, Haidan ; Ma, Qianqian ; Cui, Heying ; Liu, Guancheng ; Zhao, Xiaoyan ; Li, Wei ; Piao, Guangchun

Molecules (Basel, Switzerland), 2017-07, Vol.22 (7), p.1135 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?
Autor: Yuan, Haidan ; Ma, Qianqian ; Cui, Heying ; Liu, Guancheng ; Zhao, Xiaoyan ; Li, Wei ; Piao, Guangchun
Assuntos: Artemisinin ; Drug discovery ; Drug Discovery - methods ; Drug Interactions ; Drug Synergism ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - toxicity ; Herbs ; Humans ; Medicine ; Medicine, Traditional - methods ; network pharmacology ; Pharmacology ; R&D ; Research & development ; Review ; Synergism ; Synergistic effect ; synergistic effects ; Toxicity ; traditional medicines
É parte de: Molecules (Basel, Switzerland), 2017-07, Vol.22 (7), p.1135
Descrição: Many prescriptions of traditional medicines (TMs), whose efficacy has been tested in clinical practice, have great therapeutic value and represent an excellent resource for drug discovery. Research into single compounds of TMs, such as artemisinin from L., has achieved great success; however, it has become evident that a TM prescription (which frequently contains various herbs or other components) has a synergistic effect in effecting a cure or reducing toxicity. Network pharmacology targets biological networks and analyzes the links among drugs, targets, and diseases in those networks. Comprehensive, systematic research into network pharmacology is consistent with the perspective of holisticity, which is a main characteristic of many TMs. By means of network pharmacology, research has demonstrated that many a TM show a synergistic effect by acting at different levels on multiple targets and pathways. This approach effectively bridges the gap between modern medicine and TM, and it greatly facilitates studies into the synergistic actions of TMs. There are different kinds of synergistic effects with TMs, such as synergy among herbs, effective parts, and pure compounds; however, for various reasons, new drug discovery should at present focus on synergy among pure compounds.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?

Yuan, Haidan ; Ma, Qianqian ; Cui, Heying ; Liu, Guancheng ; Zhao, Xiaoyan ; Li, Wei ; Piao, Guangchun

Switzerland: MDPI AG

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