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The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB

Ahmed, Yasar Luqman ; Gerke, Jennifer ; Park, Hee-Soo ; Bayram, Özgür ; Neumann, Piotr ; Ni, Min ; Dickmanns, Achim ; Kim, Sun Chang ; Yu, Jae-Hyuk ; Braus, Gerhard H ; Ficner, Ralf Stock, Ann M.

PLoS Biology, 2013-12, Vol.11 (12), p.e1001750-e1001750 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB
Autor: Ahmed, Yasar Luqman ; Gerke, Jennifer ; Park, Hee-Soo ; Bayram, Özgür ; Neumann, Piotr ; Ni, Min ; Dickmanns, Achim ; Kim, Sun Chang ; Yu, Jae-Hyuk ; Braus, Gerhard H ; Ficner, Ralf
Stock, Ann M.
Assuntos: Aspergillus nidulans - genetics ; Aspergillus nidulans - physiology ; Biology ; Consensus Sequence - genetics ; Consensus Sequence - physiology ; DNA sequencing ; DNA, Fungal - genetics ; DNA, Fungal - physiology ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Gene Expression Regulation, Developmental - genetics ; Gene Expression Regulation, Developmental - physiology ; Gene Expression Regulation, Fungal - genetics ; Gene Expression Regulation, Fungal - physiology ; Genes, Fungal - genetics ; Genes, Fungal - physiology ; Genes, rel - genetics ; Genes, rel - physiology ; Genetic research ; Homology (Biology) ; NF-kappa B - genetics ; NF-kappa B - physiology ; Nucleotide sequencing ; Protein binding
É parte de: PLoS Biology, 2013-12, Vol.11 (12), p.e1001750-e1001750
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: YLA JG HSP ÖB PN MN AD SCK JHY GB RF. Performed the experiments: YLA JG HSP ÖB PN MN AD. Analyzed the data: YLA JG HSP ÖB PN MN AD SCK JHY GB RF. Wrote the paper: YLA JG HSP ÖB PN AD JHY GB RF.
The authors have declared that no competing interests exist.
Descrição: Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain of VosA is a novel DNA-binding motif that specifically recognizes an 11-nucleotide consensus sequence consisting of two motifs in the promoters of key developmental regulatory genes. The crystal structure analysis of the VosA velvet domain revealed an unforeseen structural similarity with the Rel homology domain (RHD) of the mammalian transcription factor NF-κB. Based on this structural similarity several conserved amino acid residues present in all velvet domains have been identified and shown to be essential for the DNA binding ability of VosA. The velvet domain is also involved in dimer formation as seen in the solved crystal structures of the VosA homodimer and the VosA-VelB heterodimer. These findings suggest that defence mechanisms of both fungi and animals might be governed by structurally related DNA-binding transcription factors.
Editor: United States: Public Library of Science
Idioma: Inglês

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The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB

Ahmed, Yasar Luqman ; Gerke, Jennifer ; Park, Hee-Soo ; Bayram, Özgür ; Neumann, Piotr ; Ni, Min ; Dickmanns, Achim ; Kim, Sun Chang ; Yu, Jae-Hyuk ; Braus, Gerhard H ; Ficner, Ralf Stock, Ann M.

United States: Public Library of Science

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