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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

Birge, R B ; Boeltz, S ; Kumar, S ; Carlson, J ; Wanderley, J ; Calianese, D ; Barcinski, M ; Brekken, R A ; Huang, X ; Hutchins, J T ; Freimark, B ; Empig, C ; Mercer, J ; Schroit, A J ; Schett, G ; Herrmann, M

Cell death and differentiation, 2016-06, Vol.23 (6), p.962-978 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Autor: Birge, R B ; Boeltz, S ; Kumar, S ; Carlson, J ; Wanderley, J ; Calianese, D ; Barcinski, M ; Brekken, R A ; Huang, X ; Hutchins, J T ; Freimark, B ; Empig, C ; Mercer, J ; Schroit, A J ; Schett, G ; Herrmann, M
Assuntos: Animals ; Antibodies - immunology ; Antibodies - therapeutic use ; Apoptosis ; Apoptosis - physiology ; Apoptosis Regulatory Proteins - metabolism ; Asymmetry ; Autoimmunity ; Biochemistry ; Cancer ; Cell death ; Communicable Diseases - immunology ; Communicable Diseases - metabolism ; Communicable Diseases - pathology ; Glycerol ; Hospitals ; Humans ; Immunology ; Infections ; Infectious diseases ; Internal medicine ; Membrane Glycoproteins - metabolism ; Membranes ; Neoplasms - immunology ; Neoplasms - metabolism ; Neoplasms - pathology ; Oncology ; Pathogens ; Phosphatidylserines - immunology ; Phosphatidylserines - metabolism ; Physiology ; Proteins ; Receptors, Cell Surface - metabolism ; Review ; Signal Transduction
É parte de: Cell death and differentiation, 2016-06, Vol.23 (6), p.962-978
Notas: These authors contributed equally to this work.
Descrição: Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in physiology by sculpting complex tissues during embryogenesis and by removing effete cells that have reached advanced age or whose genomes have been irreparably damaged. Apoptosis culminates in the rapid and decisive removal of cell corpses by efferocytosis, a term used to distinguish the engulfment of apoptotic cells from other phagocytic processes. Over the past decades, the molecular and cell biological events associated with efferocytosis have been rigorously studied, and many eat-me signals and receptors have been identified. The externalization of phosphatidylserine (PS) is arguably the most emblematic eat-me signal that is in turn bound by a large number of serum proteins and opsonins that facilitate efferocytosis. Under physiological conditions, externalized PS functions as a dominant and evolutionarily conserved immunosuppressive signal that promotes tolerance and prevents local and systemic immune activation. Pathologically, the innate immunosuppressive effect of externalized PS has been hijacked by numerous viruses, microorganisms, and parasites to facilitate infection, and in many cases, establish infection latency. PS is also profoundly dysregulated in the tumor microenvironment and antagonizes the development of tumor immunity. In this review, we discuss the biology of PS with respect to its role as a global immunosuppressive signal and how PS is exploited to drive diverse pathological processes such as infection and cancer. Finally, we outline the rationale that agents targeting PS could have significant value in cancer and infectious disease therapeutics.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

Birge, R B ; Boeltz, S ; Kumar, S ; Carlson, J ; Wanderley, J ; Calianese, D ; Barcinski, M ; Brekken, R A ; Huang, X ; Hutchins, J T ; Freimark, B ; Empig, C ; Mercer, J ; Schroit, A J ; Schett, G ; Herrmann, M

England: Nature Publishing Group

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