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Himalayan Nettle Girardinia diversifolia as a Candidate Ingredient for Pharmaceutical and Nutraceutical Applications-Phytochemical Analysis and In Vitro Bioassays

Sharan Shrestha, Shyam ; Sut, Stefania ; Ferrarese, Irene ; Barbon Di Marco, Serena ; Zengin, Gokhan ; De Franco, Michele ; Pant, Deepak Raj ; Mahomoodally, Mohamad Fawzi ; Ferri, Nicola ; Biancorosso, Noemi ; Maggi, Filippo ; Dall Acqua, Stefano ; Rajbhandary, Sangeeta

Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1563 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Himalayan Nettle Girardinia diversifolia as a Candidate Ingredient for Pharmaceutical and Nutraceutical Applications-Phytochemical Analysis and In Vitro Bioassays
Autor: Sharan Shrestha, Shyam ; Sut, Stefania ; Ferrarese, Irene ; Barbon Di Marco, Serena ; Zengin, Gokhan ; De Franco, Michele ; Pant, Deepak Raj ; Mahomoodally, Mohamad Fawzi ; Ferri, Nicola ; Biancorosso, Noemi ; Maggi, Filippo ; Dall Acqua, Stefano ; Rajbhandary, Sangeeta
Assuntos: Acetylcholinesterase ; Anticholesteremic Agents - isolation & purification ; Anticholesteremic Agents - pharmacology ; Antioxidants ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Ascorbic acid ; Ascorbic Acid - isolation & purification ; Ascorbic Acid - pharmacology ; Bioassays ; Biological assays ; Carotenoids ; Carotenoids - isolation & purification ; Carotenoids - pharmacology ; Cell Line, Tumor ; Cell Survival - drug effects ; Cholesterol ; Chromatography ; Cosmetics ; Cytotoxicity ; Cytotoxins - isolation & purification ; Cytotoxins - pharmacology ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; Enzymes ; Fatty acids ; Fatty Acids - isolation & purification ; Fatty Acids - pharmacology ; Flowers & plants ; Functional foods & nutraceuticals ; Glucosidase ; Glucosides - isolation & purification ; Glucosides - pharmacology ; Homeostasis ; Humans ; Ions ; LC-MS ; LDLR ; Leaves ; Linolenic acid ; Low density lipoprotein receptors ; Mass spectrometry ; Medical treatment ; Metabolites ; NMR ; Ovarian cancer ; Pancreas ; Pancreatic cancer ; Pharmaceuticals ; Phenols ; Phenylpropionates - isolation & purification ; Phenylpropionates - pharmacology ; Phytochemicals ; Phytochemicals - isolation & purification ; Phytochemicals - pharmacology ; Phytosterols ; Phytosterols - isolation & purification ; Phytosterols - pharmacology ; Plant Extracts - chemistry ; Polyphenols ; Polyphenols - isolation & purification ; Polyphenols - pharmacology ; Receptor density ; Receptors, LDL - antagonists & inhibitors ; Receptors, LDL - genetics ; Receptors, LDL - metabolism ; Riboflavin - isolation & purification ; Riboflavin - pharmacology ; Saponins ; Saponins - isolation & purification ; Saponins - pharmacology ; Scientific imaging ; Secondary metabolites ; Sensors ; Sitosterols - isolation & purification ; Sitosterols - pharmacology ; Tuberculosis ; Tumor cell lines ; Tyrosinase ; Urticaceae - chemistry ; α-Amylase ; α-Glucosidase
É parte de: Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1563
Descrição: , also known as Himalayan nettle, is a perennial herb used in Nepal to make fiber as well as in traditional medicine for the treatment of several diseases. To date, phytochemical studies and biological assays on this plant are scarce. Thus, in the present work, the extracts have been evaluated for their potential pharmaceutical, cosmetic and nutraceutical uses. For this purpose, detailed phytochemical analyses were performed, evidencing the presence of phytosterols, fatty acids, carotenoids, polyphenols and saponins. The most abundant secondary metabolites were β- and γ-sitosterol (11 and 9% dw, respectively), and trans syringin (0.5 mg/g) was the most abundant phenolic. Fatty acids with an abundant portion of unsaturated derivatives (linoleic and linolenic acid at 22.0 and 9.7 mg/g respectively), vitamin C (2.9 mg/g) and vitamin B2 (0.12 mg/g) were also present. The antioxidant activity was moderate while a significant ability to inhibit acetylcholinesterase (AChE), butyrilcholinesterase (BuChE), tyrosinase, α-amylase and α-glucosidase was observed. A cytotoxic effect was observed on human ovarian, pancreatic and hepatic cancer cell lines. The effect in hepatocarcinoma cells was associated to a downregulation of the low-density lipoprotein receptor (LDLR), a pivotal regulator of cellular cholesterol homeostasis. These data show the potential usefulness of this species for possible applications in pharmaceuticals, nutraceuticals and cosmetics.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Himalayan Nettle Girardinia diversifolia as a Candidate Ingredient for Pharmaceutical and Nutraceutical Applications-Phytochemical Analysis and In Vitro Bioassays

Sharan Shrestha, Shyam ; Sut, Stefania ; Ferrarese, Irene ; Barbon Di Marco, Serena ; Zengin, Gokhan ; De Franco, Michele ; Pant, Deepak Raj ; Mahomoodally, Mohamad Fawzi ; Ferri, Nicola ; Biancorosso, Noemi ; Maggi, Filippo ; Dall Acqua, Stefano ; Rajbhandary, Sangeeta

Switzerland: MDPI AG

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