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Involvement of Prolactin-Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake

Yamashita, M. ; Takayanagi, Y. ; Yoshida, M. ; Nishimori, K. ; Kusama, M. ; Onaka, T.

Journal of neuroendocrinology, 2013-05, Vol.25 (5), p.455-465 [Periódico revisado por pares]

Oxford: Blackwell Publishing Ltd

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  • Título:
    Involvement of Prolactin-Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake
  • Autor: Yamashita, M. ; Takayanagi, Y. ; Yoshida, M. ; Nishimori, K. ; Kusama, M. ; Onaka, T.
  • Assuntos: Animals ; Biological and medical sciences ; CCK ; Feeding Behavior ; food intake ; Fundamental and applied biological sciences. Psychology ; Male ; Neurons - metabolism ; Neurons - pathology ; Neurons - physiology ; Original ; oxytocin ; Oxytocin - physiology ; Prolactin-Releasing Hormone - physiology ; PrRP ; Rats ; Rats, Wistar ; vasopressin ; Vertebrates: endocrinology
  • É parte de: Journal of neuroendocrinology, 2013-05, Vol.25 (5), p.455-465
  • Notas: Grants-in-Aid for Scientific Research - No. 23390052
    istex:70CE394E9860AA1FF4E435EA8A2AB033C1909532
    Cooperative Basic and Clinical Research on Circadian Medicine
    ArticleID:JNE12019
    Exploratory Research - No. 90177254; No. 22659050; No. 24790236; No. 24790237
    ark:/67375/WNG-XB841WQ8-3
    Strategic Research Program for Brain Sciences
    Grants-in-Aid for Scientific Research on Innovative Areas - No. 4303; No. 24120517; No. 3217; No. 23126524
    Japan Society for the Promotion of Science
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    ObjectType-Article-2
    ObjectType-Feature-1
  • Descrição: Food intake activates neurones expressing prolactin‐releasing peptide (PrRP) in the medulla oblongata and oxytocin neurones in the hypothalamus. Both PrRP and oxytocin have been shown to have an anorexic action. In the present study, we investigated whether the activation of oxytocin neurones following food intake is mediated by PrRP. We first examined the expression of PrRP receptors (also known as GPR10) in rats. Immunoreactivity of PrRP receptors was observed in oxytocin neurones and in vasopressin neurones in the paraventricular and supraoptic nuclei of the hypothalamus and in the bed nucleus of the stria terminalis. Application of PrRP to isolated supraoptic nuclei facilitated the release of oxytocin and vasopressin. In mice, re‐feeding increased the expression of Fos protein in oxytocin neurones of the hypothalamus and bed nucleus of the stria terminalis. The increased expression of Fos protein in oxytocin neurones following re‐feeding or i.p. administration of cholecystokinin octapeptide (CCK), a peripheral satiety factor, was impaired in PrRP‐deficient mice. CCK‐induced oxytocin increase in plasma was also impaired in PrRP‐deficient mice. Furthermore, oxytocin receptor‐deficient mice showed an increased meal size, as reported in PrRP‐deficient mice and in CCKA receptor‐deficient mice. These findings suggest that PrRP mediates, at least in part, the activation of oxytocin neurones in response to food intake, and that the CCK–PrRP–oxytocin pathway plays an important role in the control of the termination of each meal.
  • Editor: Oxford: Blackwell Publishing Ltd
  • Idioma: Inglês
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