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Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy

Thadani, Udho ; Fung, Ho-Leung ; C. Darke, Andrew ; Parker, John O. ; Cruise, Marjery J.

The American journal of cardiology, 1982-02, Vol.49 (2), p.411-419 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy
Autor: Thadani, Udho ; Fung, Ho-Leung ; C. Darke, Andrew ; Parker, John O. ; Cruise, Marjery J.
Assuntos: Administration, Oral ; Adult ; Aged ; Angina Pectoris - drug therapy ; Delayed-Action Preparations ; Dose-Response Relationship, Drug ; Headache - chemically induced ; Humans ; Isosorbide Dinitrate - administration & dosage ; Isosorbide Dinitrate - adverse effects ; Isosorbide Dinitrate - blood ; Isosorbide Dinitrate - therapeutic use ; Male ; Middle Aged ; Physical Exertion ; Placebos ; Systole ; Time Factors
É parte de: The American journal of cardiology, 1982-02, Vol.49 (2), p.411-419
Descrição: The effects of different oral doses of isosorbide dinitrate administered acutely and four times daily during sustained therapy were studied in 12 patients with angina pectoris. After administration of 30, 60 and 120 mg of isosorbide dinitrate, the average plasma concentrations were higher and the area under the plasma concentration time curve was greater during sustained than during acute therapy (p < 0.01). Reduction in standing systolic blood pressure was greater during acute than during sustained therapy (p < 0.001). This reduction in systolic blood pressure was dose-related and persisted for 8 hours during acute therapy, but was not dose-related and was demonstrable for only 4 hours during sustained therapy. Compared with placebo therapy, exercise duration to the onset of angina and to the development of moderate angina increased significantly after each dose of isosorbide dinitrate for 8 hours during acute therapy but for only 2 hours during sustained therapy. During acute therapy, administration of a single dose of 15 or 30 mg of isosorbide dinitrate produced similar improvement in exercise tolerance as did a dose of 60 or 120 mg. During sustained therapy (15 mg four times daily), exercise tolerance increased to the same magnitude as with doses of 30, 60 or 120 mg four times daily. In most patients, near maximal improvement in exercise tolerance occurred after a dose of 15 or 30 mg four times daily. It is concluded that during sustained therapy with isosorbide dinitrate, partial tolerance to the antianginal and circulatory effects develops rapidly.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy

Thadani, Udho ; Fung, Ho-Leung ; C. Darke, Andrew ; Parker, John O. ; Cruise, Marjery J.

United States: Elsevier Inc

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