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The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes

Oakley, Berl R Kozminski, Keith

Molecular biology of the cell, 2023-01, Vol.34 (1), p.rt1-rt1 [Periódico revisado por pares]

United States: The American Society for Cell Biology

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  • Título:
    The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes
  • Autor: Oakley, Berl R
  • Kozminski, Keith
  • Assuntos: Aspergillus nidulans - metabolism ; Fungal Proteins - metabolism ; Microtubule-Associated Proteins - metabolism ; Microtubule-Organizing Center - metabolism ; Microtubules - metabolism ; Retrospective ; Tubulin - metabolism
  • É parte de: Molecular biology of the cell, 2023-01, Vol.34 (1), p.rt1-rt1
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: For many years, two central, unanswered questions in cytoskeleton research were how microtubule assembly is nucleated and microtubule polarity established. The discoveries of γ-tubulin and γ-tubulin ring complexes were key advances that allowed these questions to be substantially answered. The discovery of γ-tubulin was the product of a genetic screen in for genes important for microtubule function. γ-Tubulin is a member of the tubulin superfamily of proteins, closely related to α- and β-tubulin but distinct from both. It is ubiquitous in eukaryotes, and in many organisms there are small families of γ-tubulin genes. γ-Tubulin and associated proteins form ring-like complexes that localize to microtubule-organizing centers (MTOCs) and play an important role in the nucleation of microtubule assembly from MTOCs and the establishment of microtubule polarity.
  • Editor: United States: The American Society for Cell Biology
  • Idioma: Inglês
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