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Study on the assay of proximal tubular antigen in urine and serum with an anti-human renal monoclonal antibody

TANIAI, KAZUHI

The Japanese Journal of Nephrology, 1991, Vol.33(10), pp.939-947

Japan: Japanese Society of Nephrology

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  • Título:
    Study on the assay of proximal tubular antigen in urine and serum with an anti-human renal monoclonal antibody
  • Autor: TANIAI, KAZUHI
  • Assuntos: Animals ; Antibodies, Monoclonal ; Antigens - analysis ; Antigens - urine ; Enzyme-Linked Immunosorbent Assay ; Glomerulonephritis - immunology ; glonerulonephritis ; Humans ; Kidney Tubules, Proximal - immunology ; Mice ; monoclonal antibody ; proximal tubular antigen ; sandwich ELISA ; urinary renal antigen
  • É parte de: The Japanese Journal of Nephrology, 1991, Vol.33(10), pp.939-947
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: Monoclonal antibodies (Mabs) were produced by immunizing mice with human kidney microsomal antigen. Mab-B1 recognized brushborder (Bl-Ag) in proximal tubules. Using Mab-B1, B1-Ag was assayed in the urine and serum of renal disease patients by sandwich ELISA. The subjects included normal control (Nor), minimal change nephrotic syndrome (MCNS), IgA nephropathy (IgA), membranous nephropathy (MN), membranoproliferative glomerulonephritis (MPGN), and chronic renal failure (CRF) (s-Cr>2 mg/dl). Urinary B1-Ag demonstrated significant increases in the IgA (p<0.001), MN (p<0.001), MPGN (p<0.001) and CRF (p<0.01) groups as compared to the Nor group. There was no significant increase in the MCNS group. In the CRF group, B1-Ag in urine showed a significant increase in the progressive CRF group with 4s-Cr>1.0 mg/dl/month as compared to the stationary CRF group with 4s-Cr< 1.0 mg/dl/month. No correlation was observed between urinary B1-Ag and proteinuria, hematuria, s-Cr, s-BMG and u-NAG. The above findings suggested that the assay of urinary Bl-Ag was useful as a new parameter in detecting the site and degree of proximal tubular damage.
  • Editor: Japan: Japanese Society of Nephrology
  • Idioma: Japonês
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