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Loading and releasing ciprofloxacin in photoactivatable liposomes

Ghosh, Sanjana ; Qi, Ruiquan ; Carter, Kevin A. ; Zhang, Guojian ; Pfeifer, Blaine A. ; Lovell, Jonathan F.

Biochemical engineering journal, 2019-01, Vol.141, p.43-48 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Loading and releasing ciprofloxacin in photoactivatable liposomes
  • Autor: Ghosh, Sanjana ; Qi, Ruiquan ; Carter, Kevin A. ; Zhang, Guojian ; Pfeifer, Blaine A. ; Lovell, Jonathan F.
  • Assuntos: Antibiotics ; Ciprofloxacin ; Drug delivery ; Light triggered release ; Liposomes ; Porphyrin-phospholipid
  • É parte de: Biochemical engineering journal, 2019-01, Vol.141, p.43-48
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •Ciprofloxacin was loaded into photoactivatable liposomes containing porphyrin-phospholipid.•A formulation was optimized for antibiotic loading, stability and fast light-triggered drug release.•Liposomes released their content in less than 30 s under 665 nm irradiation.•Antimicrobial activity of released ciprofloxacin was observe in vitro against Bacillus subtilis. We demonstrate that ciprofloxacin can be actively loaded into liposomes that contain small amounts of porphyrin-phospholipid (PoP). PoP renders the liposomes photoactivatable, so that the antibiotic is released from the carrier under red light irradiation (665 nm). The use of 2 mole % PoP in the liposomes accommodated active loading of ciprofloxacin. Further inclusion of 2 mole % of an unsaturated phospholipid accelerated light-triggered drug release, with more than 90% antibiotic release from the liposomes occurring in less than 30 s. With or without laser treatment, ciprofloxacin PoP liposomes inhibited the growth of Bacillus subtilis in liquid media, apparently due to uptake of the liposomes by the bacteria. However, when liposomes were first separated from smaller molecules with centrifugal filtration, only the filtrate from laser-treated liposomes was bactericidal, confirming effective release of active antibiotic. These results establish the feasibility of remote loading antibiotics into photoactivatable liposomes, which could lead to opportunities for enhanced localized antibiotic therapy.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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