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Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation

Alolga, Raphael N. ; Opoku-Damoah, Yaw ; Alagpulinsa, David A. ; Huang, Feng-Qing ; Ma, Gaoxiang ; Chavez Leon, Maria A.S.C. ; Kudzai, Chifodya ; Yin, Xiaojian ; Ding, Yang

Biomaterials, 2021-01, Vol.268, p.120482-120482, Article 120482 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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  • Título:
    Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation
  • Autor: Alolga, Raphael N. ; Opoku-Damoah, Yaw ; Alagpulinsa, David A. ; Huang, Feng-Qing ; Ma, Gaoxiang ; Chavez Leon, Maria A.S.C. ; Kudzai, Chifodya ; Yin, Xiaojian ; Ding, Yang
  • Assuntos: Metabolomics ; Reconstituted high-density lipoprotein ; Rheumatoid arthritis ; Transcriptomics ; Xylopic acid
  • É parte de: Biomaterials, 2021-01, Vol.268, p.120482-120482, Article 120482
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Xylopic acid (XA), a diterpene kaurene and the major active ingredient of the African spice Xylopia aethiopica (Annonaceae), is reported to possess anti-inflammatory and analgesic properties. Here, we investigated the therapeutic potential of XA for rheumatoid arthritis (RA), a debilitating autoimmune inflammatory disease characterized by joint damage, in the complete Freund's adjuvant (CFA)-induced arthritis model in rats. We synthesized bioinspired reconstituted high-density lipoprotein (rHDL) nanoparticles loaded with purified XA crystals (rHDL/XA) that passively accumulate in inflamed joints of CFA-induced arthritic rats. Treatment with rHDL/XA minimized mononuclear cell infiltration of CFA-induced arthritic sites and ameliorated disease burden. Metabolomic and transcriptomic analyses revealed that the major molecular pathways perturbed following CFA-induced arthritis correlated with amino acid and lipid metabolism, which were restored to normal states by rHDL/XA treatment. This work demonstrates the anti-RA potential of XA in a nanoformulation and uncovers its underlying therapeutic mechanisms at the transcript and metabolite levels.
  • Editor: Netherlands: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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