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Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

McKnite, Autumn M ; Perez-Munoz, Maria Elisa ; Lu, Lu ; Williams, Evan G ; Brewer, Simon ; Andreux, Pénélope A ; Bastiaansen, John W M ; Wang, Xusheng ; Kachman, Stephen D ; Auwerx, Johan ; Williams, Robert W ; Benson, Andrew K ; Peterson, Daniel A ; Ciobanu, Daniel C White, Bryan A.

PloS one, 2012-06, Vol.7 (6), p.e39191-e39191 [Peer Reviewed Journal]

United States: Public Library of Science

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Title:
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits
Author: McKnite, Autumn M ; Perez-Munoz, Maria Elisa ; Lu, Lu ; Williams, Evan G ; Brewer, Simon ; Andreux, Pénélope A ; Bastiaansen, John W M ; Wang, Xusheng ; Kachman, Stephen D ; Auwerx, Johan ; Williams, Robert W ; Benson, Andrew K ; Peterson, Daniel A ; Ciobanu, Daniel C
White, Bryan A.
Subjects: Analysis ; Anatomy & physiology ; Animal sciences ; Animals ; Bacteria ; Bacteroidaceae - classification ; Bacteroidaceae - genetics ; Bacteroidetes ; Biological response modifiers ; Biology ; chain fatty-acids ; Chromosome Mapping ; Chromosomes, Mammalian ; diet ; Digestive system ; Digestive tract ; expression ; Firmicutes ; Food science ; Gastrointestinal system ; Gastrointestinal tract ; Gene expression ; Gene mapping ; Gene sequencing ; Gene-Environment Interaction ; Genes ; Genetic aspects ; Genetic diversity ; Genetic factors ; Genetic Variation ; Genetics ; genome-wide association ; Genome-Wide Association Study ; Genomes ; Genomics ; Host-Pathogen Interactions ; House mouse ; Immunological tolerance ; Immunology ; inbred mouse strains ; induced obesity ; innate immunity ; Interferon ; Intestinal microflora ; Intestine ; Intestines - microbiology ; Laboratories ; Lactobacillus ; Linkage analysis ; Loci ; Metabolism ; Metagenome ; Mice ; Microbial activity ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Neurobiology ; Neurosciences ; Obesity ; Pathogens ; Physiological aspects ; Physiological effects ; Physiology ; Polygenic inheritance ; Population ; Population genetics ; Quantitative genetics ; Quantitative Trait Loci ; Signaling ; Studies ; Taxa ; Toll-like receptors ; Variation ; weight ; Zoology
Is Part Of: PloS one, 2012-06, Vol.7 (6), p.e39191-e39191
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: DC AB DP LL RW. Performed the experiments: DC AM JA LL EW PA. Analyzed the data: AM MPM SB JB XW SK AB DP DC. Contributed reagents/materials/analysis tools: DC DP AB RW JA. Wrote the paper: DC AM MPM SB JA RW AB DP.
Description: The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a combination of environmental and host genetic factors and is associated with several polygenic diseases. In this study we combined next-generation sequencing, genetic mapping, and a set of physiological traits of the BXD mouse population to explore genetic factors that explain differences in gut microbiota and its impact on metabolic traits. Molecular profiling of the gut microbiota revealed important quantitative differences in microbial composition among BXD strains. These differences in gut microbial composition are influenced by host-genetics, which is complex and involves many loci. Linkage analysis defined Quantitative Trait Loci (QTLs) restricted to a particular taxon, branch or that influenced the variation of taxa across phyla. Gene expression within the gastrointestinal tract and sequence analysis of the parental genomes in the QTL regions uncovered candidate genes with potential to alter gut immunological profiles and impact the balance between gut microbial communities. A QTL region on Chr 4 that overlaps several interferon genes modulates the population of Bacteroides, and potentially Bacteroidetes and Firmicutes-the predominant BXD gut phyla. Irak4, a signaling molecule in the Toll-like receptor pathways is a candidate for the QTL on Chr15 that modulates Rikenellaceae, whereas Tgfb3, a cytokine modulating the barrier function of the intestine and tolerance to commensal bacteria, overlaps a QTL on Chr 12 that influence Prevotellaceae. Relationships between gut microflora, morphological and metabolic traits were uncovered, some potentially a result of common genetic sources of variation.
Publisher: United States: Public Library of Science
Language: English

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Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

McKnite, Autumn M ; Perez-Munoz, Maria Elisa ; Lu, Lu ; Williams, Evan G ; Brewer, Simon ; Andreux, Pénélope A ; Bastiaansen, John W M ; Wang, Xusheng ; Kachman, Stephen D ; Auwerx, Johan ; Williams, Robert W ; Benson, Andrew K ; Peterson, Daniel A ; Ciobanu, Daniel C White, Bryan A.

United States: Public Library of Science

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