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Monoamine oxidase: radiotracer chemistry and human studies

Fowler, Joanna S. ; Logan, Jean ; Shumay, Elena ; Alia-Klein, Nelly ; Wang, Gene-Jack ; Volkow, Nora D.

Journal of labelled compounds & radiopharmaceuticals, 2015-03, Vol.58 (3), p.51-64 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Monoamine oxidase: radiotracer chemistry and human studies
  • Autor: Fowler, Joanna S. ; Logan, Jean ; Shumay, Elena ; Alia-Klein, Nelly ; Wang, Gene-Jack ; Volkow, Nora D.
  • Assuntos: Brain - enzymology ; Drug Discovery ; Genotype ; human studies ; Humans ; Inhibitor drugs ; monoamine oxidase ; Monoamine Oxidase - chemistry ; Monoamine Oxidase - genetics ; Monoamine Oxidase - metabolism ; PET ; positron emission tomography (PET) facility ; RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY ; Radioactive Tracers ; Radiochemistry - methods ; radiotracer chemistry ; Studies
  • É parte de: Journal of labelled compounds & radiopharmaceuticals, 2015-03, Vol.58 (3), p.51-64
  • Notas: ark:/67375/WNG-M0R8Q46Q-0
    Dedicated to Prof. Dr. Bengt Långström, with deepest appreciation, to celebrate his outstanding life-long contribution to the field of radiochemistry and on the occasion of his retirement as editor of the Journal of Labelled Compounds and Radiopharmaceuticals.
    istex:36F9D43C66192EC9F4B40B2D9C0DCC669002B494
    This article is published in Journal of Labelled Compounds and Radiopharmaceuticals as a special issue on 'Bengt Långström', edited by Antony Gee, Department of Chemistry and Biology, Division of Imaging Sciences and Bioengineering, Kings College London, UK and Albert Windhorst, Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
    ArticleID:JLCR3247
    Dedicated to Prof. Dr. Bengt Långström, with deepest appreciation, to celebrate his outstanding life‐long contribution to the field of radiochemistry and on the occasion of his retirement as editor of the Journal of Labelled Compounds and Radiopharmaceuticals.
    This article is published in Journal of Labelled Compounds and Radiopharmaceuticals as a special issue on ‘Bengt Långström‘, edited by Antony Gee, Department of Chemistry and Biology, Division of Imaging Sciences and Bioengineering, Kings College London, UK and Albert Windhorst, Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    BNL-107778-2015-JA
    SC00112704
    USDOE Office of Science (SC), Biological and Environmental Research (BER)
  • Descrição: Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serotonin, norepinephrine, and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson's disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 years since the first radiotracers were developed and the first positron emission tomography (PET) images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variables that have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe the following: (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological, and psychiatric disorders; and (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers that are currently used and possible new applications. Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating their concentration. In this article, we describe the following: (i) development of MAO radiotracers; (ii) human positron emission tomography studies including the relationship of brain MAO levels to genotype, personality, neurological, and psychiatric disorders; and (iii) the use of MAO radiotracers in drug research and development. We summarize some outstanding needs to improve the radiotracers that are currently used and possible new applications.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês;Francês;Alemão
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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