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Haploidentical Transplantation for Leukemia

Kanda, Junya ; Chao, Nelson J. ; Rizzieri, David A.

Current oncology reports, 2010-09, Vol.12 (5), p.292-301 [Periódico revisado por pares]

New York: Current Science Inc

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  • Título:
    Haploidentical Transplantation for Leukemia
  • Autor: Kanda, Junya ; Chao, Nelson J. ; Rizzieri, David A.
  • Assuntos: Clinical Trials as Topic ; Graft Survival ; Hematopoietic Stem Cell Transplantation ; Histocompatibility ; HLA Antigens - metabolism ; Humans ; Leukemia - therapy ; Medicine ; Medicine & Public Health ; Oncology ; Transplantation, Homologous
  • É parte de: Current oncology reports, 2010-09, Vol.12 (5), p.292-301
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Hematopoietic stem cell transplantation from human leukocyte antigen (HLA)-haploidentical family members offers a potential cure for patients in need of allogeneic immunotherapy who have no immediate access to an HLA-matched donor. The use of ex vivo T-cell–depleted stem cells combined with immuno-myeloablative conditioning has enabled durable donor engraftment with a low incidence of acute graft-versus-host disease despite the HLA disparity. Moreover, additional transplant techniques involving in vivo T-cell depletion and reduced-intensity conditioning have further minimized the risks. However, a major drawback is delayed immune reconstitution leading to infections and high relapse rates, prompting significant research efforts focused on improving recovery in the post-transplant period. Infusions with donor lymphocytes are common, though newer manipulations with a focus on donor natural killer cells hold great promise, as do other modified donor T-cell infusions. Success of these new procedures will make haploidentical transplants safer and more effective, further broadening its appeal.
  • Editor: New York: Current Science Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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