Idioma:

Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

Bruen, Peita D. ; McGeown, William J. ; Shanks, Michael F. ; Venneri, Annalena

Brain (London, England : 1878), 2008-09, Vol.131 (9), p.2455-2463 [Periódico revisado por pares]

Oxford: Oxford University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Autor: Bruen, Peita D. ; McGeown, William J. ; Shanks, Michael F. ; Venneri, Annalena
Assuntos: Aged ; Aged, 80 and over ; agitation ; Alzheimer Disease - pathology ; Alzheimer Disease - psychology ; Alzheimer's disease ; apathy ; Atrophy - pathology ; Biological and medical sciences ; Brain - pathology ; Brain Mapping - methods ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; delusions ; Delusions - etiology ; Delusions - pathology ; dementia ; Female ; Humans ; Lethargy - etiology ; Lethargy - pathology ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; MRI ; Neurology ; Neuropsychological Tests ; Psychomotor Agitation - etiology ; Psychomotor Agitation - pathology ; voxel-based morphometry
É parte de: Brain (London, England : 1878), 2008-09, Vol.131 (9), p.2455-2463
Notas: istex:F00DCEE67E4C47533210748AEBD703FB342A8479
ArticleID:awn151
ark:/67375/HXZ-VQ4QR56B-1
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Alzheimer's disease research has largely concentrated on the study of cognitive decline, but the associated behavioural and neuropsychiatric symptoms are of equal importance in the clinical profile of the disease. There is emerging evidence that regional differences in brain atrophy may align with variant disease presentations. The objective of this study was to identify the regions of decreased grey matter (GM) volume which were associated with specific neuropsychiatric behaviours in patients with mild Alzheimer's disease. Voxel-based morphometry was used to correlate GM derived from T1-weighted MRI images of 31 patients with mild Alzheimer's disease and specific neuropsychiatric symptoms and behaviours measured by the Neuropsychiatric Inventory. Delusions were associated with decreased GM density in the left frontal lobe, in the right frontoparietal cortex and in the left claustrum. Apathy was associated with GM density loss in the anterior cingulate and frontal cortex bilaterally, the head of the left caudate nucleus and in bilateral putamen. Agitation was associated with decreased GM values in the left insula, and in anterior cingulate cortex bilaterally. Neuropsychiatric symptoms of Alzheimer's disease seem to associate with neurodegeneration of specific neural networks supporting personal memory, reality monitoring, processing of reward, interoceptive sensations and subjective emotional experience. The study of neurodegenerative disorders such as Alzheimer's disease using voxel-based morphometry and other imaging modalities may further the understanding of the neural structures that mediate the genesis of abnormal behaviours.
Editor: Oxford: Oxford University Press
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

Bruen, Peita D. ; McGeown, William J. ; Shanks, Michael F. ; Venneri, Annalena

Oxford: Oxford University Press

Buscando em bases de dados remotas. Favor aguardar.