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Prevalence and association of frailty with SARS-CoV-2 infection in older adults in Southern Switzerland-Findings from the Corona Immunitas Ticino Study

Jiang, Miao ; Corna, Laurie ; Amati, Rebecca ; Piumatti, Giovanni ; Franscella, Giovanni ; Crivelli, Luca ; Albanese, Emiliano

BMC geriatrics, 2023-01, Vol.23 (1), p.18-18, Article 18 [Periódico revisado por pares]

England: BioMed Central Ltd

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  • Título:
    Prevalence and association of frailty with SARS-CoV-2 infection in older adults in Southern Switzerland-Findings from the Corona Immunitas Ticino Study
  • Autor: Jiang, Miao ; Corna, Laurie ; Amati, Rebecca ; Piumatti, Giovanni ; Franscella, Giovanni ; Crivelli, Luca ; Albanese, Emiliano
  • Assuntos: Aged ; Care and treatment ; Cohort Studies ; COVID-19 ; COVID-19 - epidemiology ; Epidemiology ; Female ; Frail Elderly ; Frailty ; Frailty - diagnosis ; Frailty - epidemiology ; Geriatric Assessment ; Geriatrics ; Health aspects ; Humans ; Male ; Methods ; Older adults ; Pandemics ; Prevalence ; SARS-CoV-2 ; Services ; Switzerland - epidemiology ; Vulnerability (Psychology)
  • É parte de: BMC geriatrics, 2023-01, Vol.23 (1), p.18-18, Article 18
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
  • Descrição: Frailty is an age-associated state of increased vulnerability to stressors that strongly predicts poor health outcomes. Epidemiological evidence on frailty is limited during the COVID-19 pandemic, and whether frailty is associated with the risk of infection is unknown. We derived a robust Frailty Index (FI) to measure the prevalence of frailty and its risk factors in community-dwelling older adults in Southern Switzerland (Ticino), and we explored the association between frailty and serologically confirmed SARS-CoV-2 infection. In September 2020, we recruited a random sample of community-dwelling older adults (65 +) in the Corona Immunitas Ticino prospective cohort study (CIT) and assessed a variety of lifestyle and health characteristics. We selected 30 health-related variables, computed the Rockwood FI, and applied standard thresholds for robust (FI < 0.1), pre-frail (0.1 ≤ FI < 0.21), and frail (FI ≥ 0.21). Complete data for the FI was available for 660 older adults. The FI score ranged between zero (no frailty) and 0.59. The prevalence of frailty and pre-frailty were 10.3% and 48.2% respectively. The log-transformed FI score increased by age similarly in males and females, on average by 2.8% (p < 0.001) per one-year increase in age. Out of 481 participants with a valid serological test, 11.2% were seropositive to either anti-SARS-CoV-2 IgA or IgG. The frailty status and seropositivity were not statistically associated (p = 0.236). Advanced age increases the risk of frailty. The risk of COVID-19 infection in older adults may not differ by frailty status.
  • Editor: England: BioMed Central Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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