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0112 Sleep-Dependent Motor Sequence Memory Consolidation in Individuals with Periodic Limb Movements

Ray, L B ; Sergeeva, V ; Viczko, J ; Owen, A M ; Fogel, S M

Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A44-A44 [Periódico revisado por pares]

US: Oxford University Press

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  • Título:
    0112 Sleep-Dependent Motor Sequence Memory Consolidation in Individuals with Periodic Limb Movements
  • Autor: Ray, L B ; Sergeeva, V ; Viczko, J ; Owen, A M ; Fogel, S M
  • Assuntos: Animal memory ; Sleep deprivation
  • É parte de: Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A44-A44
  • Descrição: Abstract Introduction Periodic limb movements (PLMs) during sleep increase with age and are associated with striatal neurodegeneration and dopamine deficiency. Limb movements are often associated with disruptions to non-rapid eye movement (NREM) sleep. Motor skill memory consolidation recruits the striatum and learning-dependent striatal activation is associated with NREM sleep. Therefore, we investigated whether individuals who experience significantly elevated levels of PLMs (but have not been formally diagnosed with periodic limb movement disorder) had learning and sleep-related memory deficits, and whether these deficits were related to sleep quality and symptom severity. Methods In total, 14 adults with PLMs (PLM group), 15 age-matched controls (CTRL group), and 14 age-matched “disturbed sleep” controls (by inducing leg movements via transcutaneous electrical muscle stimulation; CTRL-ES group) participated. All participants underwent a baseline and an experimental night of sleep. On the experimental night, participants were trained (10PM) and retested (10AM) on a procedural motor sequence learning (MSL) task. The post-training sleep of the CTRL-ES group was disturbed by experimentally induced leg movements. Results Baseline sleep quality (e.g., total sleep time, sleep efficiency, number of awakenings and wake after sleep onset) was significantly worse in PLM than in CTRL. Despite the continued presence of PLMs in the PLM group on the experimental night, remarkably, sleep quality improved and arousals decreased, vs. baseline, and did not differ from CTRL. MSL was significantly slower in the PLM group than in CTRLs at training but, surprisingly, exhibited overnight performance gains, which correlated with reduced arousals. As predicted, CTRL, but not CTRL-ES, had overnight gains in MSL. Taken together, this suggests that following MSL, sleep quality was normalized in individuals who suffer from PLMs, where they derived the same benefit of sleep to procedural memory consolidation as CTRLs. Conclusion These results suggest that MSL in individuals with PLMs may provide a benefit to sleep, which in turn may benefit memory consolidation. Support (If Any) This research was funded by a Canada Excellence Research Chair Grant to AMO.
  • Editor: US: Oxford University Press
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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