skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

Extracellular Vesicles From Sporothrix brasiliensis Are an Important Virulence Factor That Induce an Increase in Fungal Burden in Experimental Sporotrichosis

Ikeda, Marcelo Augusto Kazuo ; de Almeida, José Roberto Fogaça ; Jannuzzi, Grasielle Pereira ; Cronemberger-Andrade, André ; Torrecilhas, Ana Cláudia Trocoli ; Moretti, Nilmar Silvio ; da Cunha, Julia Pinheiro Chagas ; de Almeida, Sandro Rogério ; Ferreira, Karen Spadari

Frontiers in microbiology, 2018-10, Vol.9, p.2286-2286 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

Texto completo disponível

Citações Citado por
  • Título:
    Extracellular Vesicles From Sporothrix brasiliensis Are an Important Virulence Factor That Induce an Increase in Fungal Burden in Experimental Sporotrichosis
  • Autor: Ikeda, Marcelo Augusto Kazuo ; de Almeida, José Roberto Fogaça ; Jannuzzi, Grasielle Pereira ; Cronemberger-Andrade, André ; Torrecilhas, Ana Cláudia Trocoli ; Moretti, Nilmar Silvio ; da Cunha, Julia Pinheiro Chagas ; de Almeida, Sandro Rogério ; Ferreira, Karen Spadari
  • Assuntos: dendritic cells ; extracellular vesicles ; Microbiology ; Sporothrix brasiliensis ; sporotrichosis ; virulence factor
  • É parte de: Frontiers in microbiology, 2018-10, Vol.9, p.2286-2286
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Edited by: Leonardo Nimrichter, Universidade Federal do Rio de Janeiro, Brazil
    This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology
    Reviewed by: José Ascención Martínez-Álvarez, Universidad de Guanajuato, Mexico; Daniel Zamith Miranda, Albert Einstein College of Medicine, United States
  • Descrição: Sporotrichosis is a mycosis that affects the skin, lymphatic system and other organs in humans and animals. The disease has a worldwide distribution, with endemic areas in Brazil, and is caused by a complex of species, including . Some fungi release extracellular vesicles (EVs) that can interact with the host cell and modulate the host immune response. The aim of this study was to analyze the participation of EVs in the modulation of dendritic cells (DCs) and in the control of infection . Our results showed that , the EVs isolated from induced an increase in the phagocytic index and fungal burden in DCs. In addition, we observed a significant increase in IL-12p40 and TNF-α cytokine production. Then, the EVs were inoculated into BALB/c mice before subcutaneous infection with yeast, and the lesion was analyzed after 21, 35, and 42 days. An increase in fungal burden and lesion diameter were observed after 21 days in mice inoculated with a high concentration of EVs. However, after 35 days, we observed a regression of the lesion, which persisted until 42 days after infection. Interestingly, we observed an increase in fungal burden in these mice. In addition, we observed the presence of immunogenic components and proteins that could be related with virulence in EVs. These results suggest that EVs can play an important role in virulence and modulation of the host immune system during experimental infection.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.