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Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

Gandin, Valentina ; Fernandes, Aristi P

Molecules, 2015-07, Vol.20 (7), p.12732-12756 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents
Autor: Gandin, Valentina ; Fernandes, Aristi P
Assuntos: Animals ; anticancer agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Auranofin - chemical synthesis ; Auranofin - pharmacology ; Aurothioglucose - chemical synthesis ; Aurothioglucose - pharmacology ; enzyme inhibitors ; Enzyme Inhibitors - chemical synthesis ; Enzyme Inhibitors - pharmacology ; Humans ; Isoenzymes - antagonists & inhibitors ; Isoenzymes - chemistry ; Medicin och hälsovetenskap ; metal- and semimetal-based compounds ; Models, Molecular ; Neoplasm Proteins - antagonists & inhibitors ; Neoplasm Proteins - chemistry ; Neoplasms - drug therapy ; Neoplasms - enzymology ; Neoplasms - pathology ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - pharmacology ; Oxidative Stress ; Phosphines - chemical synthesis ; Phosphines - pharmacology ; Review ; Ruthenium Compounds - chemical synthesis ; Ruthenium Compounds - pharmacology ; thioredoxin reductase ; Thioredoxin-Disulfide Reductase - antagonists & inhibitors ; Thioredoxin-Disulfide Reductase - chemistry
É parte de: Molecules, 2015-07, Vol.20 (7), p.12732-12756
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide disulfide oxidoreductases playing a central role in cellular redox homeostasis and signaling pathways. Recently, these selenoproteins have emerged as promising therapeutic targets for anticancer drug development, often being overexpressed in tumor cells and contributing to drug resistance. Herein, we summarize the current knowledge on metal- and semimetal-containing molecules capable of hampering mammalian TrxRs, with an emphasis on compounds reported in the last decade.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

Gandin, Valentina ; Fernandes, Aristi P

Switzerland: MDPI AG

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