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Computerized cognitive training for children with neurofibromatosis type 1: a pilot resting-state fMRI study

Yoncheva, Yuliya N ; Hardy, Kristina K ; Lurie, Daniel J ; Somandepalli, Krishna ; Yang, Lanbo ; Vezina, Gilbert ; Kadom, Nadja ; Packer, Roger J ; Milham, Michael P ; Castellanos, F. Xavier ; Acosta, Maria T

Psychiatry research. Neuroimaging, 2017-08, Vol.266, p.53-58 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Computerized cognitive training for children with neurofibromatosis type 1: a pilot resting-state fMRI study
Autor: Yoncheva, Yuliya N ; Hardy, Kristina K ; Lurie, Daniel J ; Somandepalli, Krishna ; Yang, Lanbo ; Vezina, Gilbert ; Kadom, Nadja ; Packer, Roger J ; Milham, Michael P ; Castellanos, F. Xavier ; Acosta, Maria T
Assuntos: Adolescent ; BOLD ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain Mapping - methods ; Brain training ; Child ; Cognitive Remediation - methods ; Female ; Fractional amplitude of low frequency fluctuations ; Functional Neuroimaging - methods ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Memory, Short-Term - physiology ; Neurofibromatosis 1 - rehabilitation ; NF1 ; Pediatric ; Pilot Projects ; Psychiatry ; Radiology ; Regional homogeneity ; Working memory
É parte de: Psychiatry research. Neuroimaging, 2017-08, Vol.266, p.53-58
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Descrição: Abstract In this pilot study, we examined training effects of a computerized working memory program on resting state functional magnetic resonance imaging (fMRI) measures in children with neurofibromatosis type 1 (NF1). We contrasted pre- with post-training resting state fMRI and cognitive measures from 16 participants (nine males; 11.1±2.3 years) with NF1 and documented working memory difficulties. Using non-parametric permutation test inference, we found significant regionally specific differences (family-wise error corrected) in two of four voxel-wise resting state measures: fractional amplitude of low frequency fluctuations (indexing peak-to-trough intensity of spontaneous oscillations) and regional homogeneity (indexing local intrinsic synchrony). Some cognitive task improvement was observed as well. These preliminary findings suggest that regionally specific changes in resting state fMRI indices may be associated with treatment-related cognitive amelioration in NF1. Nevertheless, current results must be interpreted with caution pending independent controlled replication.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Computerized cognitive training for children with neurofibromatosis type 1: a pilot resting-state fMRI study

Yoncheva, Yuliya N ; Hardy, Kristina K ; Lurie, Daniel J ; Somandepalli, Krishna ; Yang, Lanbo ; Vezina, Gilbert ; Kadom, Nadja ; Packer, Roger J ; Milham, Michael P ; Castellanos, F. Xavier ; Acosta, Maria T

Netherlands: Elsevier B.V

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