Idioma:

Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: a pediatric case report

Tsuge, Mitsuru ; Miyamoto, Machiko ; Miyawaki, Reiji ; Kondo, Yoichi ; Tsukahara, Hirokazu

BMC pediatrics, 2020-01, Vol.20 (1), p.15-15, Article 15 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: a pediatric case report
Autor: Tsuge, Mitsuru ; Miyamoto, Machiko ; Miyawaki, Reiji ; Kondo, Yoichi ; Tsukahara, Hirokazu
Assuntos: Adenoviruses ; Anemia ; Antibiotics ; Antigens ; Autoimmune diseases ; B cells ; Bacteremia ; Bacterial infections ; Blood tests ; Bone marrow ; C-reactive protein ; Care and treatment ; Case Report ; Case reports ; Case studies ; Child ; Complications and side effects ; Cyclosporins ; Cytomegalovirus ; Diagnosis ; Disease ; Diseases ; Families & family life ; Family medical history ; Ferritin ; Fever ; Hemophagocytic lymphohistiocytosis ; Hospitalization ; Humans ; Immunoglobulins ; Incidence ; Infant ; Infection ; Influenza ; Interleukins ; Intravenous immunoglobulins ; Invasive pneumococcal disease ; Lymphatic diseases ; Lymphohistiocytosis, Hemophagocytic - complications ; Lymphohistiocytosis, Hemophagocytic - diagnosis ; Lymphohistiocytosis, Hemophagocytic - drug therapy ; Male ; Measles ; Meningitis ; Meropenem ; Neutropenia ; Otitis ; Otitis media ; Pediatric diseases ; Pediatric research ; Pediatrics ; Penicillin ; Penicillin G ; Pneumococcal conjugate vaccine ; Pneumococcal infections ; Pneumococcal Infections - complications ; Pneumococcal Infections - diagnosis ; Pneumococcal Infections - drug therapy ; Pneumococcal Vaccines ; Pneumonia ; Serogroup ; Serotype replacement ; Sodium ; Splenomegaly ; Streptococcus infections ; Streptococcus pneumoniae ; Triglycerides ; Tumor necrosis factor-TNF ; Vaccines ; Vaccines, Conjugate ; Viruses
É parte de: BMC pediatrics, 2020-01, Vol.20 (1), p.15-15, Article 15
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: Hemophagocytic lymphohistiocytosis (HLH) is an infrequent but life-threatening disease due to excessive immune activation. Secondary HLH can be triggered by infections, autoimmune diseases, and malignant diseases. Streptococcus pneumoniae is a pathogenic bacterium responsible for invasive pneumococcal disease (IPD) such as meningitis and bacteremia. Although the pneumococcal conjugate vaccine (PCV) has led to reductions in IPD incidence, cases of IPD caused by serotypes not included in PCV are increasing. There are few reports of secondary HLH caused by IPD in previously healthy children. We herein report a rare case of a previously healthy boy with secondary HLH complicating IPD of serotype 23A, which is not included in the pneumococcal 13-valent conjugate vaccine (PCV-13). An 11-month-old boy who had received three doses of PCV-13 was hospitalized with prolonged fever, bilateral otitis media, neutropenia and elevated C-reactive protein (CRP) levels. Blood culture on admission revealed S. pneumoniae, leading to a diagnosis of IPD. HLH was diagnosed based on a prolonged fever, neutropenia, anemia, hepatosplenomegaly, hemophagocytosis in the bone marrow, and elevated serum levels of triglycerides, ferritin, and soluble interleukin-2 receptor. He received broad-spectrum antibiotics and intravenous immunoglobulins for IPD and high-dose steroid pulse therapy and cyclosporine A for HLH; thereafter, his fever resolved, and laboratory findings improved. The serotype of the isolated S. pneumoniae was 23A, which is not included in PCV-13. It is important to consider secondary HLH as a complication of IPD cases with febrile cytopenia or hepatosplenomegaly, and appropriate treatment for HLH should be started without delay.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: a pediatric case report

Tsuge, Mitsuru ; Miyamoto, Machiko ; Miyawaki, Reiji ; Kondo, Yoichi ; Tsukahara, Hirokazu

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.