skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Search For:
Clear Search Box
Search in:
Busca Geral
Or hit Enter to replace search target
Or select another collection:
Search in:
Busca Geral
Busca Avançada
Busca por Índices
This feature requires javascript
Tipo de recurso
criteria input
qualquer lugar do registro
no título
como autor
no assunto
Data de publicação
lsr01
lsr02
lsr03
lsr04
Orientador
Show Results with:
no título
Show Results with:
qualquer lugar do registro
no título
como autor
no assunto
Data de publicação
lsr01
lsr02
lsr03
lsr04
Orientador
Mostra resultados com:
criteria input
que contêm minhas palavras de busca
com a frase exata
começa com
Mostra resultados com:
Índice
criteria input
E
OU
NÃO
This feature requires javascript
Purinergic Signalling in the
Cochlea
Vlajkovic, Srdjan M ; Thorne, Peter R
International journal of molecular sciences, 2022-11, Vol.23 (23), p.14874
[Periódico revisado por pares]
Switzerland: MDPI AG
Texto completo disponível
Citações
Citado por
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
Nº de Citações
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
Purinergic Signalling in the
Cochlea
Autor:
Vlajkovic, Srdjan M
;
Thorne, Peter R
Assuntos:
Acoustics
;
Adenosine
;
Adenosine - metabolism
;
adenosine receptors
;
Adenosine Triphosphate - metabolism
;
Animals
;
Apoptosis
;
ATP
;
Cochlea
;
Cochlea
- metabolism
;
ectonucleotidases
;
Frequency dependence
;
G protein-coupled receptors
;
Hair
;
Hearing
;
Hearing - physiology
;
Hearing loss
;
Homeostasis
;
Injury prevention
;
Intracellular signalling
;
Ion channels
;
Mammals - metabolism
;
Metabolites
;
Neurotransmission
;
Oxidative stress
;
P2X receptors
;
P2Y receptors
;
Physiological responses
;
Purine P2 receptors
;
Purine P2X receptors
;
Purine P2Y receptors
;
Regeneration
;
Review
;
Selectivity
;
Sense organs
;
Sensory transduction
;
Signal transduction
;
Signal Transduction - physiology
;
Signaling
;
Stria vascularis
;
Supports
É parte de:
International journal of molecular sciences, 2022-11, Vol.23 (23), p.14874
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
The mammalian
cochlea
is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues. Two families of P2 receptors, ATP-gated ion channels (P2X receptors) and G protein-coupled P2Y receptors, activate intracellular signalling pathways that regulate cochlear development, homeostasis, sensory transduction, auditory neurotransmission and response to stress. Of particular interest is a purinergic hearing adaptation, which reflects the critical role of the P2X receptor in adaptive cochlear response to elevated sound levels. Other P2 receptors are involved in the maturation of neural processes and frequency selectivity refinement in the developing
cochlea
. Extracellular ATP signalling is regulated by a family of surface-located enzymes collectively known as "ectonucleotidases" that hydrolyse ATP to adenosine. Adenosine is a constitutive cell metabolite with an established role in tissue protection and regeneration. The differential activation of A and A adenosine receptors defines the cochlear response to injury caused by oxidative stress, inflammation, and activation of apoptotic pathways. A receptor agonism, A receptor antagonism, and increasing adenosine levels in cochlear fluids all represent promising therapeutic tools for cochlear rescue from injury and prevention of hearing loss.
Editor:
Switzerland: MDPI AG
Idioma:
Inglês
Links
View this record in MEDLINE/PubMed
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript