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Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania

Urnikyte, Alina ; Molyte, Alma ; Kučinskas, Vaidutis

Genes, 2021-10, Vol.12 (11), p.1730 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
Autor: Urnikyte, Alina ; Molyte, Alma ; Kučinskas, Vaidutis
Assuntos: Balto-Slavic populations ; Divergence ; effective population size ; Europeanization ; Female ; Gene polymorphism ; Genetic analysis ; Genetic diversity ; Genetic relationship ; Genetics, Population - methods ; Genomes ; Genotyping Techniques ; Haplotypes ; High-Throughput Nucleotide Sequencing ; Humans ; Lithuania - ethnology ; Male ; Middle Aged ; Neolithic ; Polymorphism, Single Nucleotide ; Population ; Population Density ; Population genetics ; Population structure ; Population studies ; Positive selection ; Principal components analysis ; Sequence Analysis, DNA ; Single-nucleotide polymorphism ; Software ; Whites - ethnology ; Whites - genetics ; Y chromosomes
É parte de: Genes, 2021-10, Vol.12 (11), p.1730
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: There are still several unanswered questions regarding about ancient events in the Lithuanian population. The Lithuanians, as the subject of this study, are of great interest as they represent a partially isolated population maintaining an ancient genetic composition and show genetic uniqueness in European comparisons. To elucidate the genetic relationships between the Lithuania and North-Eastern European and West Siberian populations, we analyzed the population structure, effective population size, and recent positive selection from genome-wide single nucleotide polymorphism (SNP) data. We identified the close genetic proximity of Lithuanians to neighboring populations (Latvians, Estonians, Belarusians) and in part with West and South Slavs (Poles, Slovaks, and Slovenians), however, with particular genetic distinctiveness. The estimated long-term values ranged from ~5900 in the Estonian population to ~2400 in the South Russian population. The divergence times between the Lithuanian and study populations ranged from 240 to 12,871 YBP. We also found evidence of selection in 24 regions, 21 of which have not been discovered in previous analyses of selection. Undoubtedly, the genetic diversity analysis of geographically specific regions may provide new insights into microevolutionary processes affecting local human populations.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania

Urnikyte, Alina ; Molyte, Alma ; Kučinskas, Vaidutis

Switzerland: MDPI AG

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