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A five-level classification system for proteoform identifications

Smith, Lloyd M ; Thomas, Paul M ; Shortreed, Michael R ; Schaffer, Leah V ; Fellers, Ryan T ; LeDuc, Richard D ; Tucholski, Trisha ; Ge, Ying ; Agar, Jeffrey N ; Anderson, Lissa C ; Chamot-Rooke, Julia ; Gault, Joseph ; Loo, Joseph A ; Paša-Tolić, Ljiljana ; Robinson, Carol V ; Schlüter, Hartmut ; Tsybin, Yury O ; Vilaseca, Marta ; Vizcaíno, Juan Antonio ; Danis, Paul O ; Kelleher, Neil L

Nature methods, 2019-10, Vol.16 (10), p.939-940 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
A five-level classification system for proteoform identifications
Autor: Smith, Lloyd M ; Thomas, Paul M ; Shortreed, Michael R ; Schaffer, Leah V ; Fellers, Ryan T ; LeDuc, Richard D ; Tucholski, Trisha ; Ge, Ying ; Agar, Jeffrey N ; Anderson, Lissa C ; Chamot-Rooke, Julia ; Gault, Joseph ; Loo, Joseph A ; Paša-Tolić, Ljiljana ; Robinson, Carol V ; Schlüter, Hartmut ; Tsybin, Yury O ; Vilaseca, Marta ; Vizcaíno, Juan Antonio ; Danis, Paul O ; Kelleher, Neil L
Assuntos: Analytical chemistry ; BASIC BIOLOGICAL SCIENCES ; Biochemistry, Molecular Biology ; Chemical Sciences ; Genomics ; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY ; Life Sciences ; Proteomics - classification ; Proteomics - methods
É parte de: Nature methods, 2019-10, Vol.16 (10), p.939-940
Notas: SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
PMCID: PMC6857706
USDOE
AC05-76RL01830
PNNL-SA-147035
Descrição: To the editorThe term proteoform, introduced in Nature Methods in 2013 (ref. 1), has rapidly gained acceptance in the proteomics community. The challenge and importance of comprehensively identifying proteoforms in complex samples has been recognized, and reports have begun to appear of new platforms towards that end2,3,4,5. However, one interesting central ambiguity has emerged, namely determining precisely what is meant by a ‘proteoform identification’. At present, the only practical approaches for establishing the exact primary structure of a proteoform employ mass spectrometry (MS), and a wide range of MS results claim proteoform identifications6. This seemingly small matter has significant impact, as the ambiguity in what is meant by an ‘identification’ makes it difficult to compare results from different laboratories and approaches. This situation hinders the ability of the community to evaluate technological progress and to efficiently expand biological knowledge.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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A five-level classification system for proteoform identifications

United States: Nature Publishing Group

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