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GC-MS based antioxidants characterization in Saussurea heteromalla (D. Don) Hand-Mazz by inhibition of nitric oxide generation in macrophages

Saboon ; Iqbal, Asia ; Bibi, Yamin ; Afzal, Tayyiba ; Sher, Ahmad ; Qayyum, Abdul ; Akmal, Muhammad ; Almoallim, Hesham S ; Ansari, Mohammad Javed ; Zeng, Yawen

Scientific reports, 2024-05, Vol.14 (1), p.10145-10145 [Periódico revisado por pares]

England: Nature Publishing Group

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GC-MS based antioxidants characterization in Saussurea heteromalla (D. Don) Hand-Mazz by inhibition of nitric oxide generation in macrophages
Autor: Saboon ; Iqbal, Asia ; Bibi, Yamin ; Afzal, Tayyiba ; Sher, Ahmad ; Qayyum, Abdul ; Akmal, Muhammad ; Almoallim, Hesham S ; Ansari, Mohammad Javed ; Zeng, Yawen
Assuntos: Animals ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Benzene ; Chromatography ; Column chromatography ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - pharmacology ; Free radicals ; Gas Chromatography-Mass Spectrometry ; HPLC ; Lipopolysaccharides ; Lipopolysaccharides - pharmacology ; Liquid chromatography ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Medicinal plants ; Mice ; n-Hexane ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric oxide inhibition ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; RAW 264.7 ; RAW 264.7 Cells ; ROS ; Saussurea ; Saussurea - chemistry ; Saussurea heteromalla ; Water purification
É parte de: Scientific reports, 2024-05, Vol.14 (1), p.10145-10145
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: For centuries, medicinal plants have served as the cornerstone for traditional health care systems and same practice is still prevalent today. In the Himalayan region, Saussurea heteromalla holds a significant place in traditional medicine and is used to address various health issues. Despite its historical use, little exploration has focused on its potential for scavenging free radicals and reducing inflammation. Hence, our current study aims to investigate the free radical scavenging capabilities of S. heteromalla extracts. The n-hexane extract of entire plant revealed promising activity. This extract underwent extensive extraction on a larger scale. Subsequent purification, employing column chromatography, HPLC-DAD techniques, led to the identification of active compounds, confirmed via GC-MS and the NIST database as 1-O-butyl 2-O-octyl benzene-1,2-dicarboxylate and 2,4-ditert-butylphenol. Assessing the free radical scavenging properties involved utilizing RAW-264.7 macrophages activated by lipopolysaccharides. Notably, the compound 2,4-di-tert-butylphenol exhibited remarkable scavenging abilities, demonstrating over 80% inhibition of Nitric oxide. This study stands as the inaugural report on the isolation of these compounds from S. heteromalla.
Editor: England: Nature Publishing Group
Idioma: Inglês

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GC-MS based antioxidants characterization in Saussurea heteromalla (D. Don) Hand-Mazz by inhibition of nitric oxide generation in macrophages

Saboon ; Iqbal, Asia ; Bibi, Yamin ; Afzal, Tayyiba ; Sher, Ahmad ; Qayyum, Abdul ; Akmal, Muhammad ; Almoallim, Hesham S ; Ansari, Mohammad Javed ; Zeng, Yawen

England: Nature Publishing Group

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