Idioma:

tert-BuOK-mediated carbanion–yne intramolecular cyclization: synthesis of 2-substituted 3-benzylbenzofurans

Chen, Po-Yuan ; Wang, Tzu-Pin ; Huang, Keng-Shiang ; Kao, Chai-Lin ; Tsai, Jui-Chi ; Wang, Eng-Chi

Tetrahedron, 2011-12, Vol.67 (48), p.9291-9297 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
tert-BuOK-mediated carbanion–yne intramolecular cyclization: synthesis of 2-substituted 3-benzylbenzofurans
Autor: Chen, Po-Yuan ; Wang, Tzu-Pin ; Huang, Keng-Shiang ; Kao, Chai-Lin ; Tsai, Jui-Chi ; Wang, Eng-Chi
Assuntos: 2-Substituted 3-benzylbenzofurans ; 5- exo- dig Cyclization ; Carbanion–yne intramolecular cyclization ; Chemistry ; Exact sciences and technology ; Heterocyclic compounds ; Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives ; o-Iodophenol ; Organic chemistry ; Preparations and properties ; Sonogashira reaction ; Synthesis (chemistry) ; Tetrahedrons
É parte de: Tetrahedron, 2011-12, Vol.67 (48), p.9291-9297
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A mild, efficient, and regioselective carbanion–yne intramolecular cyclization mediated by t-BuOK for the synthesis of 2-substituted 3-benzylbenzofurans is developed. It was started from o-iodophenol ( 1), based on O-alkylation, and the Sonogashira reaction in sequence to produce 2-(2-phenylethynylphenoxy)-1-arylalkanones ( 5). An intramolecular carbanion–yne 5- exo- dig cyclization reaction of 5, which was mediated by t-BuOK, yielded title benzofurans in good yields. [Display omitted]
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

Links

Voltar para lista de resultados