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Acid-citrate-dextrose-phosphoenolpyruvate medium as a rejuvenant for blood storage

Hamasaki, N. ; Hirota-Chigita, C.

Transfusion (Philadelphia, Pa.), 1983-01, Vol.23 (1), p.1-7 [Periódico revisado por pares]

Edinburgh, UK: Blackwell Science Ltd

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  • Título:
    Acid-citrate-dextrose-phosphoenolpyruvate medium as a rejuvenant for blood storage
  • Autor: Hamasaki, N. ; Hirota-Chigita, C.
  • Assuntos: 2,3-Diphosphoglycerate ; Adenosine Triphosphate - blood ; Anticoagulants - pharmacology ; Blood Preservation - methods ; Citric Acid ; Diphosphoglyceric Acids - blood ; Erythrocyte Aging - drug effects ; Glucose - analogs & derivatives ; Glucose - pharmacology ; Humans ; Hydrogen-Ion Concentration ; Phosphoenolpyruvate - pharmacology ; Time Factors
  • É parte de: Transfusion (Philadelphia, Pa.), 1983-01, Vol.23 (1), p.1-7
  • Notas: ArticleID:TRF2479
    ark:/67375/WNG-3G10C96Q-5
    istex:336C8ECAB21AE19366D692F2D5813280D56A1987
    Chiyo Hirota‐Chigita, BSc, Research Assistant of Biochemistry, Department of Biochemistry, Fukuoka University School of Medicine.
    Naotaka Hamasaki, MD, PhD, Associate Professor of Biochemistry, Department of Biochemistry, Fukuoka University School of Medicine, 34 Nanakuma Johnan‐ku, Fukuoka 814‐01, Japan. (Reprint requests)
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Stored, depleted RBC were rejuvenated with respect to their levels of adenosine triphosphate (ATP), 2,3‐diphosphoglycerate (2,3‐DPG), and P50 by acid‐citrate‐dextrose per‐servatives containing phosphoenolpyruvate (PEP) without sucrose. The restorations of P50 and 2,3‐DPG were dependent on the phosphoenolpyruvate concentration. Erythrocyte P50 and 2,3‐DPG, even after treatment with these preservatives, decreased with increasing storage period, but the P50 and 2,3‐DPG of five‐week‐old blood were still higher than the corresponding values of fresh blood. ATP concentration was also increased by treating stored blood with preservatives containing phosphoenolpyruvate, but the elevated ATP of five‐week‐old blood was only about 50 percent of fresh blood. The ATP level could not be raised further by increasing phosphoenolpyruvate concentration but was improved by supplementation with adenine and nucleosides. Incubation of stored blood with 15 mM phosphoenolpyruvate was sufficient to restore ATP, 2,3‐DPG and P50 of three‐week‐old blood to nearly normal. The results of these studies indicate that sucrose is not necessary for PEP to be effective as a preservative additive.
  • Editor: Edinburgh, UK: Blackwell Science Ltd
  • Idioma: Inglês
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