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From structure to function: Route to understanding lncRNA mechanism

Graf, Johannes ; Kretz, Markus

BioEssays, 2020-12, Vol.42 (12), p.e2000027-n/a [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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  • Título:
    From structure to function: Route to understanding lncRNA mechanism
  • Autor: Graf, Johannes ; Kretz, Markus
  • Assuntos: Amino acid sequence ; Combinatorial analysis ; Conservation ; Conserved sequence ; Deoxyribonucleic acid ; DNA ; lncRNA ; Localization ; long noncoding RNA ; Proteins ; Structure-function relationships
  • É parte de: BioEssays, 2020-12, Vol.42 (12), p.e2000027-n/a
  • Notas: SourceType-Other Sources-1
    content type line 63
    ObjectType-Editorial-2
    ObjectType-Commentary-1
  • Descrição: RNAs have emerged as a major target for diagnostics and therapeutics approaches. Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility. They can fold into complex structures and interact with proteins, DNA, and other RNAs, thus modulating activity, localization, or interactome of multi‐protein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of regulatory control. Interestingly, long noncoding RNAs (lncRNAs) tend to acquire complex secondary and tertiary structures and their function—in many cases—is dependent on structural conservation rather than primary sequence conservation. Whereas for many proteins, structure and its associated function are closely connected, for lncRNAs, the structural domains that determine functionality and its interactome are still not well understood. Numerous approaches for analyzing the structural configuration of lncRNAs have been developed recently. Here, will provide an overview of major experimental approaches used in the field, and discuss the potential benefit of using combinatorial strategies to analyze lncRNA modes of action based on structural information. Long noncoding RNAs (lncRNAs) tend to acquire complex secondary and tertiary structures. Most of the structural domains that determine functionality in lncRNAs are still not well understood. Here, will introduce major approaches for analyzing lncRNA structure, which could allow prediction of lncRNA modes of action based on functional domains.
  • Editor: United States: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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